Nordihydroguaiaretic acid
Product Code:
CDX-N0178
CDX-N0178
Regulatory Status:
RUO
RUO
Shipping:
Ambient
Ambient
Storage:
Short term: +20°C. Long term: +4°C
Short term: +20°C. Long term: +4°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| CDX-N0178-G001 | 1 g | £69.00 |
Quantity:
| CDX-N0178-G005 | 5 g | £243.00 |
Quantity:
Prices exclude any Taxes / VAT
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* Rare exceptions are clearly labelled (only 0.14% of items!).
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
- Further Information
- Documents
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Further Information
Appearance:
White to light beige powder or crystals.
CAS:
500-38-9
Description:
Nordihydroguaiaretic acid (NDGA) is a potent free radical scavenger, protecting cells and tissues from oxidative stress. It is a non-selective lipoxygenase (LO) inhibitor which blocks cysteinyl leukotriene (CysLT) synthesis. It is an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases. NDGA inhibits p300 and activates autophagy. This compound shows antioxidant, antimutagenic, anticancer, antiviral and anti-inflammatory characteristics mediated through multiple signaling pathways.
EClass:
32160000
Form:
solid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H302-H315-H319-H335
InChi:
InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
InChiKey:
HCZKYJDFEPMADG-UHFFFAOYSA-N
MDL:
MFCD00002206
Molecular Formula:
C18H22O4
Molecular Weight:
302.37
Package Type:
Vial
Precautions:
P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Purity:
>97% (HPLC)
Signal word:
Warning
SMILES:
C(C(C(CC1=CC(O)=C(O)C=C1)C)C)C2=CC(O)=C(O)C=C2
Solubility Chemicals:
Soluble in DMSO or ethanol (both 100mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
Documents
References
(1) T. Nakadate, et al.; Gan 73, 841 (1982) | (2) S.J. Korn & R. Horn; Mol. Pharmacol. 38, 524 (1990) | (3) Z.Y. Wang, et al.; Mutat. Res. 261, 153 (1991) | (4) M. Pavani, et al.; Biochem. Pharmacol. 48, 1935 (1994) | (5) R.W. McDonald, et al.; Anticancer Drug Des. 16, 261 (2001) | (6) T. Seufferlein, et al.; Br. J. Cancer. 86, 1188 (2002) | (7) C.H. Lee, et al.; Exp. Cell Res. 289, 335 (2003) | (8) E. Floriano-Sanchez, et al.; Free Radic. Res. 40, 523 (2006) | (9) M. Zavodovskaya, et al.; J. Cell Biochem. 103, 624 (2008) | (10) Q. Chen; Curr. Top. Med. Chem. 9, 1636 (2009) (Review) | (11) J.M. Lu, et al.; Med. Sci. Monit. 16, RA93 (2010) (Review) | (12) T. Tezil, et al.; NPJ Aging Mech. Dis. 5, 7 (2019) | (13) G. Manda, et al.; Front. Pharmacol. 11, 151 (2020) | (14) F. Martinez, et al.; Phytomedicine 106, 154424 (2022)