LTbetaR (mouse):Fc (human) (rec.)

1mg/ml after reconstitution.

Lymphotoxin beta receptor (LTbetaR) belongs to the tumor necrosis factor receptor superfamily (TNFR) and is a key regulator of lymphoid organogenesis and inflammation. LTbetaR is primarily expressed by epithelial cells, dendritic cells (DCs), stromal cells and macrophages. LTbetaR interacts with two ligands: membrane heterotrimeric lymphotoxin LTalpha1beta2 (LT) and homotrimeric LIGHT, both expressed predominantly by activated lymphoid cells. LTbetaR signaling can activate both canonical and alternative NF-kB signaling to induce various proinflammatory chemokines and cytokines and promote apoptosis via TRAF3 and TRAF5. LTbetaR also plays a role in the development of lymphoid organs. LTbetaR (mouse):Fc treatment partially impairs the structure of secondary lymphoid organs and shows therapeutic efficacy in various models of inflammatory diseases.

32160000

<0.01EU/ug purified protein (LAL test).

solid

Lyophilized. Contains PBS.

After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.

Plastic Vial

>95% (SDS-PAGE)

The extracellular domain of mouse LTbetaR (aa 31-217) is fused at the C-terminus to the Fc portion of human IgG1.

HEK 293 cells. Produced using animal component-free medium.

Human, Mouse

Binds to mouse and human LTalpha1beta2 (Lymphotoxin beta) and LIGHT (TNFsf14).

Fc

Non-hazardous

P50284

12352202

Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.