NSJ Bioreagents

MUC5AC Antibody

Product Code:
 
NSJ-V8591BTN-SAF
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
45M1
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
 
Store the biotinylated MUC5AC antibody at 2-8oC (up to one month) or aliquot and store at -20oC (longer term).
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IHC staining of FFPE human gastric carcinoma with biotinylated MUC5AC antibody (clone 45M1). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human gastric carcinoma with biotinylated MUC5AC antibody (clone 45M1). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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NSJ-V8591BTN-SAF-100UG100 ug£537.00
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Further Information

Application Details:
Immunohistochemistry (FFPE): 2-4ug/ml for 30 minutes at RT
Application Note:
Optimal dilution of the biotinylated MUC5AC antibody should be determined by the researcher.
Description:
This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC). Its epitope is located in the C-terminal cysteine rich part of the peptide core of MUC5AC. Its epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.
Format:
Biotin Conjugate
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Immunogen:
An M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient was used as the immunogen for the biotinylated MUC5AC antibody.
Limitation:
This biotinylated MUC5AC antibody is available for research use only.
Localisation:
Cytoplasmic
Purity:
Protein G affinity chromatography
Uniprot #:
P98088

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