AdipoGen Life Sciences

BAY 11-7082

Product Code:
 
AG-CR1-0013
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term: -20°C
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Chemical Structure
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Chemical Structure

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AG-CR1-0013-M01010 mg£66.00
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AG-CR1-0013-M05050 mg£231.00
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Further Information

Alternate Names/Synonyms:
(E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile
Appearance:
White to off-white crystalline solid.
CAS:
19542-67-7
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep under inert gas.Protect from light.
InChi:
InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
InChiKey:
DOEWDSDBFRHVAP-KRXBUXKQSA-N
Long Description:
Chemical. CAS: 19542-67-7. Formula: C10H9NO2S. MW: 207.3. IkappaBalpha kinase inhibitor. NF-kappaB inhibitor. Potential anti-inflammatory agent. Apoptosis inducer. Inhibits the release of proinflammatory cytokines. NLRP3 inflammasome inhibitor. Reduces ATPase activity of the NLRP3 inflammasome. Inhibits platelet aggregation.
MDL:
MFCD00712162
Molecular Formula:
C10H9NO2S
Molecular Weight:
207.3
Package Type:
Vial
Product Description:
IkappaBalpha kinase inhibitor. NF-kappaB inhibitor. Potential anti-inflammatory agent. Apoptosis inducer. Inhibits the release of proinflammatory cytokines. NLRP3 inflammasome inhibitor. Reduces ATPase activity of the NLRP3 inflammasome. Inhibits platelet aggregation. RBR E3 ligase inhibitor. Effects by inactivating the E2-conjugating enzymes Ubc13 and UbcH7 and the E3 ligase LUBAC, preventing the formation of Lys63-linked and linear polyubiquitin chains.
Purity:
>99% (NMR)
SMILES:
CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)C=CC#N
Solubility Chemicals:
Soluble in DMSO, 100% ethanol, dichloromethane or ethyl acetate; insoluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Novel inhibitor of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J.W. Pierce, et al.; J. Biol. Chem. 272, 21096 (1997) | Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells: N. Mori, et al.; Blood 100, 1828 (2002) | Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro: M. Lappas et al.; Endocrinology 146, 1491 (2005) | Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome: C. Juliana, et al.; J. Biol. Chem. 285, 9792 (2010) | A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylations: H.S. Lee, et al.; Eur. J. Pharmacol. 627, 85 (2010) | The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system: S. Strickson, et al.; Biochem. J. 451, 427 (2013) | The impact of alpha-Lipoic acid on cell viability and expression of nephrin and ZNF580 in normal human podocytes: U. Leppert, et al.; Eur. J. Pharmacol. 810, 1 (2017)