AdipoGen Life Sciences

IHR-NAc

Product Code:
 
AG-CR1-3527
Product Group:
 
Inhibitors and Activators
Antibody Isotype:
 
n/a
Antibody Clone:
 
n/a
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term: -20°C
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Chemical Structure
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Chemical Structure

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CodeSizePrice
AG-CR1-3527-M0011 mg£71.00
Quantity:
AG-CR1-3527-M0055 mg£141.00
Quantity:
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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
5-Acetamido-2-chloro-N-[4-(2,5-dichlorobenzamido)phenyl]benzamide
Appearance:
White to grey solid.
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light.
InChi:
InChI=1S/C22H16Cl3N3O3/c1-12(29)26-16-7-9-20(25)18(11-16)22(31)28-15-5-3-14(4-6-15)27-21(30)17-10-13(23)2-8-19(17)24/h2-11H,1H3,(H,26,29)(H,27,30)(H,28,31)
InChiKey:
KEKPTYABAFCFOT-UHFFFAOYSA-N
Long Description:
Chemical. Formula: C22H16Cl3N3O3. MW: 476.7. Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane permeable Smoothened (Smo) antagonist. Acts on extra- and intracellular exposed Smo. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.
Molecular Formula:
C22H16Cl3N3O3
Molecular Weight:
476.7
Package Type:
Vial
Product Description:
Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane permeable Smoothened (Smo) antagonist. Acts on extra- and intracellular exposed Smo. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.
Purity:
>98% (NMR)
SMILES:
CC(=O)NC1=CC=C(Cl)C(=C1)C(=O)NC1=CC=C(NC(=O)C2=C(Cl)C=CC(Cl)=C2)C=C1
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation: C.W. Fan, et al.; Chem. Biol. 21, 1680 (2014)