AdipoGen Life Sciences

JNJ-38877605

Product Code:
 
SYN-1047
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term +4°C
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Chemical Structure
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Chemical Structure

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Further Information

Alternate Names/Synonyms:
JNJ38877605
Appearance:
Solid.
CAS:
943540-75-8
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C19H13F2N7/c1-27-11-13(10-23-27)16-6-7-17-24-25-18(28(17)26-16)19(20,21)14-4-5-15-12(9-14)3-2-8-22-15/h2-11H,1H3
InChiKey:
JRWCBEOAFGHNNU-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 943540-75-8. Formula: C19H13F2N7. MW: 377.4. JNJ38877605 is an orally bio-available, small-molecule, c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (c-MET enzyme and Phospho-MET IC(50) values of 4nM and 50nM, respectively) and highly specific (selective over 229 other kinases tested).
Molecular Formula:
C19H13F2N7
Molecular Weight:
377.4
Package Type:
Plastic Vial
Product Description:
JNJ38877605 is an orally bio-available, small-molecule, c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (c-MET enzyme and Phospho-MET IC(50) values of 4nM and 50nM, respectively) and highly specific (selective over 229 other kinases tested).
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors: V. Cepero, et al.; Cancer Res. 70, 7580 (2010) | Targeting c-Met in melanoma: Mechanism of resistance and efficacy of novel combinatorial inhibitor therapy: D. Etnyre, et al.; Cancer Biol. Ther. 15, 1129 (2014)