AdipoGen Life Sciences

IPI-145

Product Code:
 
SYN-1175
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term +4°C
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Chemical Structure
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Chemical Structure

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Further Information

Alternate Names/Synonyms:
IPI 145
Appearance:
Solid.
CAS:
1201438-56-3
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1
InChiKey:
SJVQHLPISAIATJ-ZDUSSCGKSA-N
Long Description:
Chemical. CAS: 1201438-56-3. Formula: C22H17ClN6O. MW: 416.9. IPI-145 is a potent, oral inhibitor of Class I phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma (IC(50) of 243 pM and 50nM), and is clinically active in patients with advanced hematological malignancies.
Molecular Formula:
C22H17ClN6O
Molecular Weight:
416.9
Package Type:
Plastic Vial
Product Description:
IPI-145 is a potent, oral inhibitor of Class I phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma (IC(50) of 243 pM and 50nM), and is clinically active in patients with advanced hematological malignancies.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

PI3K-delta and PI3K-gamma inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models: D.G. Winkler, et al.; Chem. Biol. 20, 1364 (2013) | Novel phosphoinositide 3-kinase delta,gamma inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis: D.L. Boyle, et al.; J. Pharmacol. Exp. Ther. 348, 271 (2014) | IPI-145 shows promise in CLL patients: Cancer Discov. 4, 136 (2014)