AdipoGen Life Sciences

AMG-458

Product Code:
 
SYN-1144
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term +4°C
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Chemical Structure
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Chemical Structure

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Further Information

Alternate Names/Synonyms:
AMG458
Appearance:
Solid.
CAS:
913376-83-7
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)
InChiKey:
GLBZSOQDAOLMGC-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 913376-83-7. Formula: C30H29N5O5. MW: 539.6. AMG-458 is a potent inhibitor of c-Met with an IC(50) of 60nM and displays selectivity against VEGFR2.
Molecular Formula:
C30H29N5O5
Molecular Weight:
539.6
Package Type:
Plastic Vial
Product Description:
AMG-458 is a potent inhibitor of c-Met with an IC(50) of 60nM and displays selectivity against VEGFR2.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Discovery of a potent, selective, and orally bioavailable c-Met inhibitor: 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458): L. Liu, et al.; J. Med. Chem. 51, 3688 (2008)