PD-1 Antibody [F34C9]

Product Code:

PSI-SD8647

Product Group:

Primary Antibodies

Supplier:

ProSci

Host Type:

Llama

Antibody Isotype:

sdAb

Antibody Clonality:

Monoclonal

Antibody Clone:

F3-4C9

Regulatory Status:

RUO

Target Species:

Human

Applications:

Enzyme-Linked Immunosorbent Assay (ELISA)
Flow Cytometry

Shipping:

Dry Ice

Storage:

PD-1 antibody should be stored in working aliquots at -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

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Code	Size	Price

PSI-SD8647-0.02mg

0.02mg

£167.00

Quantity:

PSI-SD8647-0.1mg

0.1mg

£515.00

Quantity:

Prices exclude any Taxes / VAT

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Further Information

Additional Names:

PD-1 Antibody: PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l, hSLE1, PD1, Programmed cell death protein 1, Protein PD-1, PDCD1, PDCD-1

Application Note:

PD-1 antibody can be used for detection of PD-1 by ELISA and FACS (10 μg/ml).

Background:

PD-1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases.

Background References:

Holling TM, Schooten E, and van Den Elsing PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum. Immunol. 2004; 65:282-90.
Ishida Y, Agata Y, Shibahara K, et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992; 11:3887-95.
Zhong X, Bai C, Gao W, et al. Suppression of expression and function of negative immune regulator PD-1 by certain pattern recognition and cytokine receptor signals associated with immune system danger. Int. Immunol. 2004; 16:1181-8.
Nishimura H, Nose M, Hiai H, et al. Development of lupus-like autoimmune diseases by the disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999; 11:141-51.

Buffer:

PD-1 Antibody is supplied in PBS.

Concentration:

1 mg/mL

Conjugate:

Unconjugated

DISCLAIMER:

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Immunogen:

PD-1 antibody was raised against a recombinant protein corresponding to amino acids 25 - 167 of human PD-1.

NCBI Gene ID #:

5133

NCBI Official Name:

programmed cell death 1

NCBI Official Symbol:

PDCD1

NCBI Organism:

Homo sapiens

Physical State:

Liquid

Protein Accession #:

NP_005009

Protein GI Number:

145559515

Purification:

PD-1 Antibody is affinity chromatography purified via Nickel column. Antibody is supplied as a His-tagged purified protein.??It also contains a myc-tag for detection.

Research Area:

Immunology,Cancer,Cell Cycle

Swissprot #:

Q15116

User NOte:

Optimal dilutions for each application to be determined by the researcher.

PD-1 Antibody [F34C9]

Further Information

Documents