ProSci

AIFM3 Antibody

Product Code:
 
PSI-4541
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
1 / 1
Western blot analysis of AIFM3 in human brain tissue lysate with AIFM3 antibody at (A) 1 and (B) 2 μg/mL.
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Western blot analysis of AIFM3 in human brain tissue lysate with AIFM3 antibody at (A) 1 and (B) 2 μg/mL.

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CodeSizePrice
PSI-4541-0.02mg0.02mg£167.00
Quantity:
PSI-4541-0.1mg0.1mg£469.00
Quantity:
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Further Information

Additional Names:
AIFM3 Antibody: AIFL, AIFL, Apoptosis-inducing factor 3, Apoptosis-inducing factor-like protein
Application Note:
AIFM3 antibody can be used for the detection of AIFM3 by Western blot at 1 - 2 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
AIFM3 Antibody: Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist.
Background References:
  • Jin Z and El Deiry WS. Overview of cell death signaling pathways. Cancer Biol. Ther.2004; 4:139-63
  • Xie Q, Lin T, Zhang Y, et al. Molecular cloning and characterization of a human AIF-like gene with the ability to induce apoptosis. J. Biol. Chem.2005; 280:19673-81.
Buffer:
AIFM3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
AIFM3 antibody was raised against a 16 amino acid synthetic peptide from near the center of human AIFM3.

The immunogen is located within amino acids 210 - 260 of AIFM3.
NCBI Gene ID #:
150209
NCBI Official Name:
apoptosis-inducing factor, mitochondrion-associated, 3
NCBI Official Symbol:
AIFM3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q96NN9
Protein GI Number:
74732608
Purification:
AIFM3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
Swissprot #:
Q96NN9
User NOte:
Optimal dilutions for each application to be determined by the researcher.