Sciencell

Human Rectal Fibroblasts

Product Code:
 
SC-2960
Product Group:
 
Primary Cells
Supplier:
 
Sciencell
Cell System:
 
Gastrointestinal Cell System
Cell Type:
 
Fibroblasts
Species:
 
Human
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Dry Ice
Storage:
 
LiquidNitrogen
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This product comes from: United States.
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Further Information

Components:
Cells only
Extra Description:
Isolated from human rectum. HRecF are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. It is recommended to use Fibroblast Medium (FM, Cat. #2301) for culturing HRecF in vitro.
Long Description:
The human rectum is located in the lower gastrointestinal tract and functions as a temporary storage site for fecal material. Rectal fibroblasts are important structural components of the rectum and are implicated in a number of diseases including ulcerative colitis, Crohn's disease, and rectal cancer. Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. The main functions of fibroblasts are to maintain the structural integrity of connective tissue and to aid in tissue repair and remodeling. Studies have shown that functional changes to human rectal fibroblasts (HRecF) can impair wound healing and affect epithelial cell proliferation in ulcerative colitis patients. In Crohn's disease, HRecF respond to intestinal inflammation by proliferating abnormally, which leads to fibrotic scarring. Primary HRecF can be used to study the pathophysiology of rectal cancer, ulcerative colitis, and Crohn's disease and to help develop therapies for these diseases. HRecF from ScienCell Research Laboratories are isolated from human rectum. HRecF are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HRecF are characterized by immunofluorescence with antibody specific to fibronectin. HRecF are negative for mycoplasma, bacteria, yeast, and fungi. HRecF are guaranteed to further expand for 15 population doublings under the conditions provided by ScienCell Research Laboratories. Recommended Medium - It is recommended to use Fibroblast Medium (FM, Cat. #2301) for culturing HRecF in vitro.