Respiratory syncytial virus (RSV) is a highly significant respiratory virus in young children, and it is the primary cause of hospitalisations, particularly bronchiolitis and pneumonia, in infants. The impact on healthcare services is escalating as the rate of hospitalisation for bronchiolitis in children rises. Moreover, RSV has a notable impact on adults aged >65 years as well. RSV is an annual seasonal epidemic, often coinciding with other prevalent viral infections like influenza and SARS-COVID, resulting in a substantial number of hospitalisations and fatalities. Therefore, it is imperative to conduct research on RSV strategies for controlling epidemics through vaccines.
Malloy, Allison MW, et al.2023; used a well-characterised murine model of RSV to investigate the development of lung-resident memory T cells in neonatal compared to adult mice. Antigen specificity was determined using MBLI’s Db RSV M187-195 tetramer conjugated to the fluorochrome APC and Kd RSV M282-90 tetramer conjugated to the fluorochrome PE. Interestingly, neonatal and adult M2- and M-specific CD8 T cells expressed comparable amounts of effector cytokines. However, the number of M2- and M-specific CD8 T cells responding to reinfection in neonatally primed mice showed a decrease, leading to a lower frequency of CD8 T cells that secreted effector cytokines (1). Overall, the data revealed additional components of the adaptive immune response in early life, are needed to offer a new perspective on vaccine design that could help young infants (1).
| Product Code | Product Name |
| TB-5018-1 | iTAg Tetramer/PE- H-2 Db RSV Tetramer-NAITNAKII PE-2 Db RSV (NAITNAKII) |
| TS-M567-1 | H-2Kd RSV M2 Tetramer-SYIGINNI-PE |
References:
- Malloy, Allison MW, et al. “Increased innate immune activation induces protective RSV-specific lung-resident memory T cells in neonatal mice.” Mucosal Immunology 16.5 (2023): 593-605.
- Hong, S., Ruan, S., Greenberg, Z. et al. Development of surface engineered antigenic exosomes as vaccines for respiratory syncytial virus. Sci Rep 11, 21358 (2021)
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