AdipoGen Life Sciences

Sirtuin 1 (human) (IntraCellular) ELISA Kit

Product Code:
 
AG-45A-0029Y
Product Group:
 
ELISA Kits
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
 
Blue Ice
Storage:
 
Short term: +4°C. Long term: +4°C
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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
Sirt01; SIR02 like Protein 01
Assay Type:
Sandwich
Detection Type:
Colorimetric
EClass:
32160000
Handling Advice:
After standard reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Plate and reagents should reach room temperature before use.
Long Description:
ELISA Assay. Detects human sirtuin1. Does not cross-react with human sirtuin2, human sirtuin5, human sirtuin5 (intact form) or human sirtuin6. Colorimetric assay. Sample Types: Cell Lysate. Range: 0.032 to 2ng/ml. Sensitivity: 30pg/ml. Sirtuins (Silent information regulators; SIRTs) deacetylate and/or ADP-ribosylate lysine residues of target proteins in an NAD+-dependent manner. Sirtuins are critical regulators of many cellular processes, including insulin secretion, the cell cycle and apoptosis. Sirtuins, in particular SIRT1, emerged as critical regulators of longevity and aging in several model organisms. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer?s disease are associated with sirtuins. SIRT1 has been suggested as potential biomarker for tumorigenesis.
NCBI, Uniprot Number:
Q96EB6
Package Type:
Box
Product Description:
Sirtuins (Silent information regulators; SIRTs) deacetylate and/or ADP-ribosylate lysine residues of target proteins in an NAD+-dependent manner. Sirtuins are critical regulators of many cellular processes, including insulin secretion, the cell cycle and apoptosis. Sirtuins, in particular SIRT1, emerged as critical regulators of longevity and aging in several model organisms. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer?s disease are associated with sirtuins. SIRT1 has been suggested as potential biomarker for tumorigenesis.
Range:
0.032 to 2ng/ml
Sample Type:
Cell Lysate
Sensitivity:
30pg/ml
Specificity:
Detects human sirtuin1. Does not cross-react with human sirtuin2, human sirtuin5, human sirtuin5 (intact form) or human sirtuin6.
Transportation:
Non-hazardous
UNSPSC Category:
ELISA Kits
UNSPSC Number:
41116126
Use & Stability:
12 months after the day of manufacturing. See expiry date on ELISA Kit box.

References

Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation: M. Hytti, et al.; Sci. Rep. 5, 17645 (2015)