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Further Information
Bioactivity:
CDK2-IN-12 (compound 10b) is a potent inhibitor of CDK2 (IC50: 11.6 uM). CDK2-IN-12 exhibits inhibition of hCA subtypes I, II, IX and XII with KI values of 3534, 638.4, 44.3 and 48.8 nM, respectively. CDK2-IN-12 shows CDK2-IN-12 showed anti-cancer effects.