Purified Anti-Human CD172a/b Antibody[SE5A5]

CD172a, also known as signal-regulatory protein α (SIRPα), src homology 2 domain-containing phosphatase substrate-1 (SHPS1), PTPNS1, BIT, MFR, and P84, is a 75-110 kD transmembrane glycoprotein involved in receptor tyrosine kinase coupled signaling pathway. It belongs to the Ig superfamily and is primarily expressed on monocytes/macrophages, granulocytes, dendritic cells, and neurons. CD172a serves as a substrate of activated receptor tyrosine kinases (RTKs). The interaction of CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration, T cell activation, macrophage fusion, and phagocytosis. CD47 (IAP) is the extracellular ligand for CD172a. SIRPα was recently demonstrated to be a specifc marker for cardiomyocytes derived from human pluripotent stem cells2.

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

≥ 1 mg/mL

Unconjugated

FCM 2 ug/mL(0.5x10⁶-1x10⁶ cells)

12 months

Recombinant Human CD172a/b protein

>98%, Protein A/G purified

Brain Ig-Like Molecule with Tyrosine-Based Activation Motifs, CD172 Antigen-Like Family Member A, Inhibitory Feceptor SHPS-1, Macrophage Fusion Receptor, MyD-1 Antig, MyD-1 Antigen, SHP Substrate 1, SHPS-1, Signal-Regulatory Protein Alpha-1, Signal-Regulatory Protein Alpha-2, Signal-Regulatory Protein Alpha-3, Sirp-Alpha-1, Sirp-Alpha-2, Sirp-Alpha-3, Tyrosine-protein phosphatase non-receptor type substrate 1, COX, SHPS, Mtco, PTPNS, MT-CO, MYD, SIRPA, BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP, MT-CO2, COII, COX2, COXII, MTCO2, MYD1, SIRP&, alpha

P78324