Elabscience

Purified Anti-Human CD72 Antibody[3F3]

Product Code:
 
AN003250P
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG2b, κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
3F3
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Shipping:
 
Ice bag
Storage:
 
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
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Human peripheral blood lymphocytes were stained with 0.2 ug Purified Anti-Human CD72 Antibody[3F3] (Right) and 0.2 ug Mouse IgG2b, κ Isotype Control (Left), followed by APC-conjugated Goat Anti-Mouse IgG Secondary Antibody, then anti-Human CD19 FITC-conjugated Monoclonal Antibody.
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Human peripheral blood lymphocytes were stained with 0.2 ug Purified Anti-Human CD72 Antibody[3F3] (Right) and 0.2 ug Mouse IgG2b, κ Isotype Control (Left), followed by APC-conjugated Goat Anti-Mouse IgG Secondary Antibody, then anti-Human CD19 FITC-conjugated Monoclonal Antibody.

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CodeSizePrice
AN003250P-25ug25ug£100.00
Quantity:
AN003250P-100ug100ug£157.00
Quantity:
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Background:
CD72 is a 39-43 kD type II membrane glycoprotein. It is a disulfide-linked homodimer belonging to C-type lectin family. CD72 is a pan-B cell marker expressed on pre-pre-B cells throughout B cell differentiation with the exception of plasma cells. It is also expressed on follicular dendritic cells, splenic red pulp macrophages (but not on peripheral blood monocytes), and liver Kupffer cells. CD72, a negative coreceptor of B cells, contains immunoreceptor tyrosine-based inhibitory motifs in the cytoplasmic domain which has been shown to recruit the tyrosine phosphatase SHP-1. Ligation of CD72 with its ligand regulates CD72 tyrosine dephosphorylation and SHP-1 dissociation to promote B cell activation and proliferation. CD100 and CD5 have been shown to be CD72 ligands. The CD100-CD72 interaction plays a role in maintenance of B cell homeostasis.
Buffer:
Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
Concentration:
≥ 1 mg/mL
Conjugation:
Unconjugated
Dilution:
FCM 2 ug/mL(0.5x106-1x106 cells)
Expiry date:
12 months
Immunogen:
Recombinant Human CD72 protein
Purification Method:
>98%, Protein A/G purified
Target Synonym:
B-Cell Differentiation Antigen CD, LYB, CD72, CD72b, LYB2, B-Cell Differentiation Antigen CD72, Lyb-2
UNIProt ID:
P21854

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