Purified Human CD63 Antibody[H5C6]

Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

≥1 mg/mL

Unconjugated

FCM 2 ug/mL(0.5x10⁶-1x10⁶ cells)

12 months

Recombinant Human CD63 protein

>98%, Protein A/G purified

CD 63, CD63 antigen (melanoma 1 antigen), CD63 antigen melanoma 1 antigen, gp55, LAMP 3, LAMP3, Lysosomal associated membrane protein 3, Lysosome associated membrane glycoprotein 3, Mast cell antigen AD1, Melanoma 1 antigen, Melanoma associated antigen ME491, Melanoma associated antigen MLA1, MGC72893, MLA 1, NGA, Ocular melanoma associated antigen, PTLGP40, Tetraspanin 30, Tspan 30, MLA, LAMP, Tetraspanin, CD antigen CD, Melanoma-associated antigen ME, Lysosomal-associated membrane protein, CD63, LAMP-3, ME491, MLA1, OMA81H, TSPAN30, CD63 antigen, CD antigen CD63, CD63 molecule, Granulophysin, Lysosomal-associated membrane protein 3, Melanoma-associated antigen ME491, Ocular melanoma-associated antigen, Tetraspanin-30, Tspan-30, LIMP, MLA1, LAMP-3

P08962