Elabscience

APC Anti-Mouse CD123 Antibody[5B11]

Product Code:
 
AN00962E
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rat
Antibody Isotype:
 
Rat IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
5B11
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Shipping:
 
Ice bag
Storage:
 
This product can be stored at 2-8°C for 24 months. Please protected from prolonged exposure to light and do not freeze.
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Staining of C57BL/6 murine bone marrow cells with FITC Anti-Mouse CD11b Antibody and APC Anti-Mouse CD123 Antibody[5B11] (left) or APC Rat IgG2a, κ Isotype Control (right). Total viable cells were used for analysis.
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Staining of C57BL/6 murine bone marrow cells with FITC Anti-Mouse CD11b Antibody and APC Anti-Mouse CD123 Antibody[5B11] (left) or APC Rat IgG2a, κ Isotype Control (right). Total viable cells were used for analysis.

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CodeSizePrice
AN00962E-50Tests50Tests£80.00
Quantity:
AN00962E-100Tests100Tests£95.00
Quantity:
AN00962E-100Testsx2100Testsx2£123.00
Quantity:
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Background:
CD123 is a 70 kD α chain subunit of the IL-3 receptor (IL-3R α). It is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind IL-3 with low affinity but cannot transduce signals without association with additional protein partners. CD123 can complex with either the common β chain (CDw131) or the IL-3R β chain (AIC2A) to form high-affinity heterodimeric IL-3 receptors. CDw131 can complex with the α subunits of the mouse IL-3R, IL-5R and GM-CSFR to form high-affinity receptors, while the IL-3 R β subunit is specific for IL-3 but binds with low affinity. IL-3 binding to the receptor complex can induce proliferation and differentiation of hematopoietic cells. The 5B11 antibody does not block binding of IL-3 to the high affinity IL-3 receptor.
Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Concentration:
5 uL/Test
Conjugation:
APC
Expiry date:
24 months
GeneID:
16188
Target Synonym:
IL-3 Receptor α chain, IL-3Rα
UNIProt ID:
Q8CII2
Usage:
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 uL of antibody per test (million cells in 100 uL staining volume or per 100 uL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

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