Elabscience

PE/Cyanine 5 Anti-Human CD192/CCR2 Antibody[K036C2]

Product Code:
 
E-AB-F1385G
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG2a, κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
K036C2
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Shipping:
 
Ice bag
Storage:
 
This product can be stored at 2-8°C for 24 months. Please protected from prolonged exposure to light and do not freeze.
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Staining of normal human peripheral blood cells with PE/Cyanine5 Anti-Human CD192 Antibody[K036C2] (filled gray histogram) or PE/Cyanine5 Mouse IgG2a, κ Isotype Control (empty black histogram). Cells in the Monocyte gate were used for analysis.
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Staining of normal human peripheral blood cells with PE/Cyanine5 Anti-Human CD192 Antibody[K036C2] (filled gray histogram) or PE/Cyanine5 Mouse IgG2a, κ Isotype Control (empty black histogram). Cells in the Monocyte gate were used for analysis.

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CodeSizePrice
E-AB-F1385G-20Tests20Tests£123.00
Quantity:
E-AB-F1385G-100Tests100Tests£223.00
Quantity:
E-AB-F1385G-100Testsx2100Testsx2£303.00
Quantity:
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This product comes from: China.
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Further Information

Background:
CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4). Two spliced variants were initially described for CCR2 (CCR2A and CCR2B). These variants differ in their terminal carboxyl tails. Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 have been associated to atherosclerotic plaques. MCP-1 is induced by modified-LDL in endothelial cells and may trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Local overexpression of MCP-1 at vessel walls induces infiltration of macrophages and formation of atherosclerotic lesions. Obesity induces an inflammatory state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation.
Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Concentration:
5 uL/Test
Conjugation:
PE/Cyanine 5
Expiry date:
24 months
GeneID:
729230
Target Synonym:
CKR2, CCR2A, CCR2B, CKR2A, CKR2B, CMKBR2, MCP-1-R, CC-CKR-2
UNIProt ID:
P41597
Usage:
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 uL of antibody per test (million cells in 100 uL staining volume or per 100 uL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

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