Elabscience

Elab Fluor®488 Anti-Mouse CD43 Antibody[S11]

Product Code:
 
E-AB-F1398L
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rat
Antibody Isotype:
 
Rat IgG2b, κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
S11
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Shipping:
 
Ice bag
Storage:
 
This product can be stored at 2-8°C for 24 months. Please protected from prolonged exposure to light and do not freeze.
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Staining of C57BL/6 murine splenocytes cells with Elab Fluor<sup>®</sup>488 Anti-Mouse CD43 Antibody[S11] (left) or Elab Fluor<sup>®</sup>488 Rat IgG2b, κ Isotype Control (right). Total viable cells were used for analysis.
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Staining of C57BL/6 murine splenocytes cells with Elab Fluor<sup>®</sup>488 Anti-Mouse CD43 Antibody[S11] (left) or Elab Fluor<sup>®</sup>488 Rat IgG2b, κ Isotype Control (right). Total viable cells were used for analysis.

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CodeSizePrice
E-AB-F1398L-50Tests50Tests£150.00
Quantity:
E-AB-F1398L-100Tests100Tests£223.00
Quantity:
E-AB-F1398L-100Testsx2100Testsx2£352.00
Quantity:
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This product comes from: China.
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Further Information

Background:
CD43, also known as Leukosialin and Ly48, is a 125 kD sialoprotein (glycosylated protein) expressed from 1.2 kBase mRNA in bone marrow-derived cells. This occurs early in development. Cells expressing CD43 include γ/δ T cells, macrophages, mature B cells, and dendritic cells. CD43 functions as an anti-adhesive surface molecule, promoted by antibody cross-linking, that releases the trailing edge of the cell during locomotion to allow movement of the cell body towards the lamellipodia. The intracellular distribution of CD43 is determined by binding to moesin, an intracellular membrane protein, which is in-turn bound in some manner to the actin cytoskeleton. Defects with CD43 function and expression retard cellular locomotion, resulting in a wide range of immune disorders. Wiscott-Alderich syndrome, and the varying degrees of its severity, is related to the dysregulation of CD43 expression.
Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Concentration:
5 uL/Test
Conjugation:
Elab Fluor®488
Expiry date:
24 months
GeneID:
20737
Target Synonym:
Ly-48
UNIProt ID:
P15702
Usage:
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 uL of antibody per test (million cells in 100 uL staining volume or per 100 uL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

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