AdipoGen Life Sciences

anti-LAG-3 mAb (blocking) (11E3) (preservative free)

Product Code:
 
AG-20B-0011PF
Product Group:
 
Primary Antibodies
Antibody Isotype:
 
Mouse IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
1.10E+04
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Monkey
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Functional Study
  • Immunocytochemistry (ICC)
  • Immunohistochemistry (IHC)
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Shipping:
 
Blue Ice
Storage:
 
Short term: +4°C. Long term: -20°C
 

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CodeSizePrice
AG-20B-0011PF-C100100 ug£341.00
Quantity:
AG-20B-0011PF-C500500 ug£1,411.00
Quantity:
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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
Lymphocyte Activation Gene-3; FDC Protein; CD223
Concentration:
0.5 mg/ml
EClass:
32160000
Endotoxin:
<0.001EU/µg purified protein or <1EU/mg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Liquid. In PBS.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Recombinant human LAG-3.
Labels - Conjugates:
Preservative Free
Long Description:
Monoclonal Antibody. Recognizes human and monkey LAG-3. Isotype: Mouse IgG1. Clone: 1.10E+04. Applications: ELISA, FUNC (Blocking), ICC, IHC, IP, WB. Liquid. In PBS. Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
NCBI, Uniprot Number:
P18627
Package Type:
Plastic Vial
Product Description:
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
Purity:
>95% (SDS-PAGE)
Source / Host:
Purified from concentrated hybridoma tissue culture supernatant.
Specificity:
Recognizes human and monkey LAG-3.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand: B. Huard, et al.; Immunogenetics 39, 213 (1994) | Characterization of the major histocompatibility complex class II binding site on LAG-3 protein: B. Huard, et al.; PNAS 94, 5744 (1997) | A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors: F. Triebel, et al.; Cancer Lett. 235, 147 (2006) | Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia: F.J. Ward, et al.; Blood 111, 680 (2008)