PD-L1 Immune Checkpoint

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PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. PD-L1 can bind to PD-1, which mediates inhibitory signals from the APC.

ProSci Inc. offers an extensive range of antibodies and supporting tools to research PD-L1. Read more about their range below, or click a link to jump to a specific section:


Risk-Free™ Single Domain Monoclonal PD-L1 Products

Llama single domain antibodies (sdAbs) offer unique characteristics amenable to many applications. These sdAbs demonstrate low nanomolar binding affinity and can be used for the various applications. Note: PD-L1 antibody should be stored in working aliquots at -20 °C, stable for up to one year. As with all antibodies, care should be taken to avoid repeated freeze thaw cycles. PD-L1 Antibodies should not be exposed to prolonged high temperatures.

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Risk-Free™ Single Domain Monoclonal PD-L1 Set
Product SetSizeContentsDescription
PD-L1 Single Domain Set
(PSI-SD8500)
20ug/ clonePSI-SD8585, PSI-SD8623, PSI-SD8639, PSI-SD8641PD-L1 antibodies were raised against a recombinant protein corresponding to amino acids 19 - 239 of human PD-L1.
Risk-Free™ Single Domain Monoclonal PD-L1 Antibodies
Cat. NumberCloneELISAWBICCIFIHCFlowFunctional
PSI-SD8585F1A12++++-+++??++-
PSI-SD8623F1C9++++-+++??++-
PSI-SD8639F6A9--+++??+++++
PSI-SD8641F2G2++++-++??--
"?"=Not yet determined, "-"=Negative, "+"=Fair, "++"=Average, "+++"=Good, "++++"=Excellent.
Click specific applications to see respective validation image.

Risk-Free™ Mouse Monoclonal PD-L1 Products

ProSci’s Risk-Free™ antibodies are monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-Free™ antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Risk-Free™ means they are guaranteed to work for their approved applications.

Risk-Free™ Mouse Monoclonal PD-L1 Set

ProSci’s Risk-Free™ Sets consists of several mAbs with different binding features allowing selection of the best clone.

Product SetSizeContentsDescription
Risk-Free PD-L1 Set
(PSI-RF16030)
20ug/ clonePSI-RF16031, PSI-RF16032, PSI-RF16035, PSI-RF16036, PSI-RF16037, PSI-RF16038PD-L1 antibodies were raised against the extracellular domain of human PD-L1.
Risk-Free™ Mouse Monoclonal PD-L1 Antibodies

ProSci Risk-Free™ PD-L1 antibodies are rigorously tested and guaranteed to work for their designated applications.

Cat. NumberELISAWBICCIFIHCFlow
PSI-RF16031++++++++++++++++++++
PSI-RF16032+++++++++++++++++++
PSI-RF16035++++++++++++++++-
PSI-RF16036+++++++++++++++++-
PSI-RF16037++++++++++++++++-
PSI-RF16038+++++++++++++++++-
"-"=Negative, "+"=Fair, "++"=Average, "+++"=Good, "++++"=Excellent.
Click specific applications to see respective validation image.

PD-L1 Matched Antibody Pairs

A sandwich ELISA was performed using the anti-PD-L1 mAbs PSI-RF16031, PSI-RF16032, PSI-RF16033, and PSI-RF16034 as the capture antibodies for the PD-1 extracellular domain antigen with anti-PD-1 sdAbs PSI-SD8585, PSI-SD8623, PSI-SD8639, and PSI-SD8641 as the detection antibodies.

TargetMatched PairCapture AntibodyDetection AntibodyHost
PD-L1 Human Matched Antibody Pair #1PSI-RFP-0301PSI-RF16031PSI-SD8585Mouse - Llama
PD-1 Human Matched Antibody Pair #2PSI-RFP-0302PSI-RF16031PSI-SD8623Mouse - Llama
PD-1 Human Matched Antibody Pair #3PSI-RFP-0303RF16031PSI-SD8639Mouse - Llama
PD-1 Human Matched Antibody Pair #4PSI-RFP-0304PSI-RFP-0302PSI-SD8585Mouse - Llama
PD-1 Human Matched Antibody Pair #5PSI-RFP-0305PSI-RFP-0302PSI-SD8623Mouse - Llama
PD-1 Human Matched Antibody Pair #6PSI-RFP-0306PSI-RFP-0302PSI-SD8639Mouse - Llama

PD-L1 human matched antibody ELISA pair by prosci


Additional PD-L1 Antibodies

Monoclonal antibodies are highly specific and recognize only one epitope on an antigen which generates consistent performance in quantitative detection applications regardless of production batch. Polyclonal antibodies have high affinity and recognize different epitopes on a specific antigen. Note: These antibodies can be stored at -20˚C and are stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.

Monoclonal PD-1 Products
Cat. NumberNameApplications
PSI-76-958CD274 Antibody [10F.9G2] Flow, Func
PSI-76-960CD274 Antibody [10F.9G2] (PE) Flow
Polyclonal PD-1 Products
Cat. NumberAntigen RangeELISAWBICCIFIHCFlow
PSI-405960 - 110++++++++++++++++++++
PSI-46-156240 - 290?+++??++++?
"?"=Not yet determined, "-"=Negative, "+"=Fair, "++"=Average, "+++"=Good, "++++"=Excellent. Click specific applications to see respective validation image.

Related PD-1 Products

Recombinant Proteins
Cat. NumberSequenceFusion TagSpeciesTissue/ Cell
PSI-90-429Aa 19 - 238Fc TagHumanCHO
PSI-90-430Aa 19 - 238Fc TagHuman [Non-Lytic]CHO
PSI-90-431Aa 19 - 237Fc TagMouseCHO
PSI-90-432Aa 19 - 237Fc TagMouse [Non-Lytic]CHO
PSI-91-293Phe 19 - Thr 239C-6 His tagHumanHuman
PSI-92-625Phe 19 - Thr 239C-Flag TagHumanHuman
PSI-96-598Phe 19 - Arg 238C-Fc TagHumanHEK293
PSI-96-599Phe 19 - Arg 238C-Twin Strep TagHumanHEK293
PSI-96-606Phe 19 - Arg 238His TagHumanHEK293
PSI-96-608Phe 19 - Thr 238His TagHumanHEK293
PSI-96-610Phe 19 - Thr 238C-Fc TagMouseHEK293
Peptides
Cat. NumberLocationSpecies
PSI-4059P17 amino acids near the center of human PD-L1 Human
PSI-46-156PPD-L1 peptide corresponds to 12 amino acids of PD-L1Human
Antigen
Cat. NumberProduct TypeSpeciesTissue/ Cell
PSI-RF16030-01Recombinant Protein HumanHEK293
Lysates
Cat. NumberProduct TypeSpeciesTissue/ Cell
PSI-RF10001-04Positive Control (Tissue Lysate) HumanTonsil
PSI-RF10001-06Positive Control (Cell Lysate) HumanRaji
PSI-RF10001-02Negative Control (Cell Lysate)HumanHEK293
Slides
Cat. NumberProduct TypeSpeciesTissue/ Cell
PSI-RF10002-04Positive Control (Cells)HumanRaji
PSI-RF10002-02Negative Control (Cells) HumanHEK293

Caltag Medsystems offers a multitude of Immune Checkpoint research products from ProSci and other supplier. If you are looking for something else, please contact us and we will be happy to help.


Further Information on PD-1

ProSci products are distributed in the UK by Caltag Medsystems. If you have any questions about the products in this blog, please contact us.

PD-L1 Immune Checkpoint
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