TargetMol

PfDHODH-IN-1

Product Code:
 
TAR-T12438
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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This product comes from: Austria.
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Further Information

Bioactivity:
PfDHODH-IN-1 is an inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase(PfDHODH) which catalyzes the rate-limiting step for DNA and RNA biosynthesis. PfDHODH-IN-1 has antimalarial activity.
CAS:
183945-55-3
Formula:
C14H11F3N2O2
Molecular Weight:
296.249
Pathway:
Metabolism; Microbiology/Virology
Purity:
0.9974
SMILES:
OC(C1CC1)=C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F
Target:
Dehydrogenase; Parasite

Documents

References

1. Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93. 2. Hou X, et al. QSAR study on the antimalarial activity of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. SAR QSAR Environ Res. 2016;27(2):101-24.