TargetMol

DL-threo-2-methylisocitrate sodium

Product Code:
 
TAR-T19291
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1 (ICL1). Using Michaelis-Menten nonlinear least squares fitting, kcat value was 5.24 s-1, the Km of the purified recombinant ICL1 of threonine-D(s)L(s)-isocitrate (ICA) was 188 μM. The Km of DL-threo-2-methylisocitrate (MICA) is approximately four times higher at 718 μM, and the kcat is 1.25 s-1.
CAS:
T19291
Formula:
C14H14Na6O14
Molecular Weight:
544.19
Purity:
0.98
SMILES:
O[C@@](C)(C([O-])=O)[C@@]([H])(C([O-])=O)CC([O-])=O.O[C@](C)(C([O-])=O)[C@]([H])(C([O-])=O)CC([O-])=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

Documents

References

1. Gould TA, et al. Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis. Mol Microbiol. 2006 Aug;61(4):940-7.