AdipoGen Life Sciences

Bisindolylmaleimide XI . hydrochloride [Ro 32-0432]

Product Code:
 
AG-CR1-0109
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term: -20°C
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Chemical Structure
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Chemical Structure

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AG-CR1-0109-M0011 mg£91.00
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AG-CR1-0109-M0055 mg£271.00
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Further Information

Alternate Names/Synonyms:
Ro 32-0432; BIM XI
Appearance:
Dark red solid.
CAS:
145333-02-4
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C28H28N4O2.ClH/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21;/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34);1H
InChiKey:
HSPRASOZRZDELU-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 145333-02-4. Formula: C28H28N4O2 . HCl. MW: 452.5 . 36.5. Selective cell permeable protein kinase C (PKC) inhibitor. G protein-coupled receptor kinase (GRK-5) inhibitor. Less potent GRK-2 or GRK-3 inhibitor. Prevents T cell-driven chronic inflammatory responses in vivo.
MDL:
MFCD01319127
Molecular Formula:
C28H28N4O2 . HCl
Molecular Weight:
452.5 . 36.5
Package Type:
Vial
Product Description:
Selective cell permeable protein kinase C (PKC) inhibitor. G protein-coupled receptor kinase (GRK-5) inhibitor. Less potent GRK-2 or GRK-3 inhibitor. Prevents T cell-driven chronic inflammatory responses in vivo.
Purity:
>98% (HPLC)
SMILES:
Cl.CN(C)CC1CCN2C(C1)=C(C1=C2C=CC=C1)C1=C(C(=O)NC1=O)C1=CN(C)C2=C1C=CC=C2
Solubility Chemicals:
Soluble in DMSO or methanol.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.

References

Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation: A.M. Birchall, et al.; J. Pharmacol. Exp. Ther. 268, 922 (1994) | Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993) | Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors, and agents in development: P.G. Goekjian & M.R. Jirousek; Curr. Med. Chem. 6, 877 (1999) (Review) | Involvement of G protein-coupled receptor kinase-6 in desensitization of CGRP receptors: N. Aiyar, et al.; Eur. J. Pharmacol. 403, 1 (2000)