Antiviral Compounds – Potential Small Molecule Therapeutics Against COVID-19
There are no approved drugs to treat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that causes coronavirus disease 2019 (COVID-19). Existing drugs, that have a known favourable safety profile, are being examined for strategies to treat the disease and fast-track a treatment plan. Several influenza and HIV drugs are currently undergoing clinical trials in coronavirus patients. The rational selection of drugs already on the market is being made based on their ability to inhibit any proteins essential for virus-receptor interaction and/or viral life cycle.
LITERATURE REFERENCES:
- Recent discovery and development of inhibitors targeting coronaviruses: T. Pillaiyar, et al.; Drug Discov. Today (Epub ahead of print) (2020)
- Rapid Identification of Potential Inhibitors of SARS-CoV-2 Main Protease by Deep Docking of 1.3 Billion Compounds: A.T. Ton, et al.; Mol. Inform. (Epub ahead of print) (2020)
- Potential inhibitors against 2019-nCoV coronavirus M protease from clinically approved medicines: X. Liu & X.J. Wang; J. Genet. Genomics 47, 119 (2020)
- Identification of FDA Approved Drugs Targeting COVID-19 Virus by Structure-Based Drug Repositioning: P. Wang, et al.; ChemRxiv (Preprint) (2020)
- Structure of Mpro from COVID-19 virus and discovery of its inhibitors: Z. Jin, et al.; Nature (Epub ahead of print) (2020)
AdipoGen Life Sciences offers a Selection of Antiviral Small Molecules as Potential Tools for in vitro Studies of COVID-19 (not for human use).
| Product Name | PID | CAS Number | Target | Antiviral Activity |
| Aloxistatin [E-64d] | AG-CR1-3737 | 88321-09-9 | Viral entry Cathepsin L | Viral Replication |
| Amastatin . hydrochloride | AG-CP3-7003 | 100938-10-1 | Viral entry ANPEP (Aminopeptidase N) | Viral Replication |
| Artesunate | AG-CN2-0469 | 88495-63-0 | NF-κB suppression | Viral Replication Cytokine Storm |
| Baricitinib | AG-CR1-3734 | 1187594-09-7 | JAK1/JAK2 / Immunomodulation AP-2 associated protein kinase 1 / Endocytosis | Viral Replication |
| Boceprevir | AG-CR1-3735 | 394730-60-0 | Main Protease (Mpro) | Viral Transcription/Replication |
| Budesonide | AG-CR1-3753 | 51333-22-3 | Glucocorticod Receptors Inflammatory Factors | Viral Replication Cytokine Storm |
| Camostat mesylate | AG-CR1-3716 | 59721-29-8 | Viral entry TMPRSS2 | Viral Replication |
| Chloroquine . diphosphate | AG-CR1-3721 | 50-63-5 | Lysosome function Zinc ionophore Immunomodulation | Viral Replication |
| Hydroxychloroquine . sulfate | AG-CR1-3720 | 747-36-4 | Lysosome function Zinc ionophore Immunomodulation | Viral Replication |
| Clevudine | AG-CR1-3736 | 163252-36-6 | RNA-dependent RNA polymerases (RdRps) | Viral Transcription/Replication |
| Darunavir | AG-CR1-3712 | 206361-99-1 | Papain-like viral protease (PLVP) | Viral Maturation/Replication |
| Darunavir . ethanolate | AG-CR1-3724 | 635728-49-3 | Papain-like viral protease (PLVP) | Viral Maturation/Replication |
| 2-Deoxy-D-glucose | AG-CR1-3681 | 154-17-6 | Glycolysis/Cell Metabolism | Viral Replication/Cytokine Storm |
| Dexamethasone | AG-CR1-3742 | 50-02-2 | Inflammatory Factors | Cytokine Storm |
| Dexamethasone phosphate . 2Na | AG-CR1-3744 | 2392-39-4 | Inflammatory Factors | Cytokine Storm |
| Dihydroartemisinin | AG-CN2-0468 | 71939-50-9 | NF-κB suppression | Viral Replication Cytokine Storm |
| Ebselen | AG-CR1-0031 | 60940-34-3 | Main Protease (Mpro)/3C-like Protease | Viral Transcription/Replication |
| EIDD-2801 (Molnupiravir) | AG-CR1-3733 | 2349386-89-4 | RNA-dependent RNA polymerases (RdRps) | Viral Transcription/Replication |
| Elbasvir | AG-CR1-3729 | 1370468-36-2 | RdRP, Papain-like Proteinase and Helicase | Viral Replication |
| Euphol | AG-CN2-0541 | 514-47-6 | Main Protease (Mpro) | Viral Transcription/Replication |
| Famotidine | AG-CR1-3730 | 76824-35-6 | SARS-CoV-2 papain-like protease (PLpro) | Viral Replication |
| Favipiravir | AG-CR1-3717 | 259793-96-9 | RNA-dependent RNA polymerases (RdRps) | Viral Transcription/Replication |
| Ibudilast | AG-CR1-3738 | 50847-11-5 | Macrophage Inhibitory Factor (MIF) Immunomodulation | Viral Replication Cytokine Storm |
| Imatinib mesylate | AG-CR1-3725 | 220127-57-1 | Virion fusion with endosomal membrane | Viral Replication |
| Leupeptin . hemisulfate | AG-CP3-7000 | 103476-89-7 | Viral entry TMPRSS2 | Viral Replication |
| Lopinavir | AG-CR1-3715 | 192725-17-0 | Coronavirus endopeptidase C30 (CEP_C30) | Viral Maturation/Replication |
| Merafloxacin | AG-CR1-3756 | 91188-00-0 | Programmed -1 Ribosomal Frameshifting | Viral Replication |
| Mycophenolic acid | AG-CN2-0419 | 24280-93-1 | SARS-CoV-2 papain-like protease (PLpro) | Viral Replication |
| Nafamostat mesylate | AG-CR1-3731 | 82956-11-4 | Viral entry TMPRSS2 | Viral Replication |
| Nelfinavir . mesylate | AG-CR1-3726 | 159989-65-8 | Post-entry inhibitor | Viral Replication |
| Niclosamide | AG-CR1-3643 | 50-65-7 | Endosome acidification | Viral Replication |
| Niclosamide . ethanolamine | AG-CR1-3644 | 1420-04-8 | Endosome acidification | Viral Replication |
| Nitazoxanide | AG-CR1-3723 | 55981-09-4 | Viral hemagglutinin Viral IE2 | Viral Maturation/ Transcription/Replication |
| Opaganib | AG-CR1-3749 | 915385-81-8 | Sphingosine Kinase 2 Inflammatory Factors | Cytokine Storm |
| Oseltamivir . phosphate | AG-CR1-3714 | 204255-11-8 | Viral neuraminidase Release of viral particles | Viral Replication |
| PX-12 | AG-CR1-3739 | 141400-58-0 | Main Protease (Mpro)/3C-like Protease | Viral Transcription/Replication |
| Remdesivir | AG-CR1-3713 | 1809249-37-3 | RNA-dependent RNA polymerases (RdRps) | Viral Transcription/Replication |
| Remdesivir Metabolite GS-441524 | AG-CR1-3722 | 1191237-69-0 | RNA-dependent RNA polymerases (RdRps) | Viral Transcription/Replication |
| Ribavirin | AG-CR1-3719 | 36791-04-5 | RNA-dependent RNA polymerases (RdRps) RNA capping activity Viral mutation rates Immunomodulation | Viral Transcription/Replication |
| Ritonavir | AG-CR1-3683 | 155213-67-5 | Coronavirus endopeptidase C30 (CEP_C30) | Viral Maturation/Replication |
| Rosuvastatin . calcium salt | AG-CR1-3728 | 147098-20-2 | Main Protease Mpro | Viral Replication |
| Ruxolitinib . phosphate salt | AG-CR1-3645 | 1092939-17-7 | JAK1/JAK2 Immunomodulation | Viral Replication |
| Ruxolitinib (free base) | AG-CR1-3624 | 941678-49-5 | JAK1/JAK2 Immunomodulation | Viral Replication |
| Saquinavir . mesylate | AG-CR1-3727 | 149845-06-7 | Main Protease Mpro | Viral Replication |
| Shikonin | AG-CN2-0487 | 517-89-5 | Main Protease (Mpro)/3C-like Protease | Viral Transcription/Replication |
| Suramin . hexasodium salt | AG-CR1-3575 | 129-46-4 | Viral Entry/Fusion RNA-dependent RNA polymerases (RdRps) | Viral Transcription/Replication |
| TDZD-8 | AG-CR1-3740 | 327036-89-5 | Main Protease (Mpro)/3C-like Protease | Viral Transcription/Replication |
| Telaprevir | AG-CR1-3741 | 402957-28-2 | 3C-like Protease | Viral Replication |
| Tofacitinib | AG-CR1-3625 | 477600-75-2 | JAK1/JAK3 Immunomodulation | Viral Replication |
| Tofacitinib citrate | AG-CR1-3732 | 540737-29-9 | JAK1/JAK3 Immunomodulation | Viral Replication |
| Tofacitinib citrate | CDX-T0461 | 540737-29-9 | JAK1/JAK3 Immunomodulation | Viral Replication |
| Umifenovir . HCl [Arbidol] | AG-CR1-3718 | 131707-23-8 | Viral entry Fusion into host cells | Viral Replication |
| VIP (human, mouse, rat) . AcOH [RLF-100] | AG-CP3-0041 | 1444827-29-5 | Viral Replication Immunomodulation | Viral Replication |
NOT FOR HUMAN USE
Originally posted on adipogen.com/covid-19
Caltag Medsystems is the distributor of Adipogen products in the UK and Ireland. If you have any questions about these products, please contact us.
Antiviral Compounds – Potential Small Molecule Therapeutics Against COVID-19