MBLI QuickSwitch™ kit technology aims to replicate the immune response by mimicking peptide exchange on an MHC molecule.
Defined Immune Response Tracking in Mice: OVA MHC Tetramers
T cell-dependent OVA antigen is used as a model protein for studying antigen-specific immune responses in mice. MBL has OVA related tetramer products.
Streamline the detection of CD4 T cells with QuickSwitch™ Class II Quant Tetramer Kits
Use QuickSwitch™ Class II Quant Tetramer to investigate peptide-MHC binding affinities & conclude with your specialised CD4+ T cell detection reagent!
2023 Advancements in Research with QuickSwitch™ Custom Tetramer Kits
Here are the highlights of some of the influential publications that have utilised MBLI QuickSwitch™ Tetramer Kits in 2023.
What Exactly is a TCR Tetramer?
A TCR Tetramer is a reagent prepared by tetramerising biotinylated antigen-specific TCRs with the help of phycobiliprotein-labelled streptavidin.
Tetramer Gating Strategy For True Positives Results
Investigators have developed a gating strategy that effectively minimises non-specific staining by incorporating a dump channel.
CD1d Tetramers for Monitoring Invariant Natural Killer T (iNKT) cells
MBL International offers CD1d tetramers prepared by tetramerisation of complexes of CD1d and β2m by PE- or APC- labelled streptavidin.
Screening for COVID-19 T-Cell Peptides and Immune Monitoring with MHC Tetramers In A Single Assay
COVID-19 infected cells can be recognized by T-cells only after SARS-CoV-2 peptides are processed and presented in the context of self MHCs. Identifying these peptides have essential utilities: Immune monitoring: Using peptide-MHC tetramers to assess vaccine-induced immunity Designing potent vaccines
Tetramers
TCRs recognize and bind to complexes composed of MHC molecules and specific peptides expressed on the surface of antigen-presenting cells. While it was once believed that antigen-specific T cells could be detected using soluble MHC/peptide complexes, monomeric MHC/peptide complexes proved
MHC Class I & II Tetramers, MHC Monomers and CD1d Tetramers
TCRs recognize and bind to complexes composed of MHC molecules and specific peptides expressed on the surface of antigen-presenting cells. We have tetramerized and biotinylated with streptavidin to maintain stable binding to multiple TCR, enabling MHC/peptide tetramers to be used