When performing staining with MHC tetramers, there may be certain cases where the staining is unclear. An example could be in certain cases where an antigen-specific T cell population of interest has a low frequency. The following tips discussed in
White Paper: Analysis of neoantigen-reactive T cells using the QuickSwitch™ custom tetramer kit
Kazuhiro Kakimi MD, PhD has been a leader in developing effective immunotherapies against cancer for the last 15 years in Japan. In this whitepaper, he and his colleagues have reported that the QuickSwitch™ Custom Tetramers will become an essential tool
QuickSwitch™ – Quickly Create Custom Tetramers
Fast, High-Quality Generation of New Tetramer Specificities Rapid, high-quality creation of custom class I tetramers is now a reality! Create new specificity tetramers in just a few hours with QuickSwitch™ from MBL International; a proprietary technology for exchanging peptides on
Class II MHC Tetramers Available from MBL International
T cell receptors (TCRs) expressed on the surface of T cells specifically recognize and bind to complexes of major histocompatibility complex (MHC) molecules and peptide fragments. CD4+ T cells, which include helper and regulatory T cells, recognize complexes of MHC class
New Alleles added to the MHC Class I Tetramer Range
T-Cell Receptors (TCRs) recognise and bind to complexes composed of Major Histocompatibility Complex (MHC) molecules and specific peptides expressed on the surface of antigen-presenting cells. T cell receptors (TCRs) expressed on the surface of T cells specifically recognise and bind
Help! My mouse tetramer stained ALL the CD8+ T cells!
You’re sitting at your flow cytometer, staring at your CD8 x tetramer plot in anticipation of a tiny but meaningful group of dots appearing in the upper right quadrant. You hold your breath, click “acquire,” and watch… Wait, what? What’s
Up to 50% off Cryopreserved PBMCs
Get 50% off ZenBio’s Cryopreserved Peripheral Blood Mononuclear Cells until the end of the year! Contact us with promo code ‘ZEN50PMBC’ to redeem this.
Cervical cancer is the fourth most common cancer affecting women: Antigen-Specific Detection of HPV and HSV
Cervical cancer is the 4th most prevalent cancer among women, and the 7th most common cancer. MBLI provides HPV-related tetramers for use in research.
Protective Role of Invariant Natural Killer T (iNKT) cells
CD1d, non-classical MHC molecules, present phospholipid & glycosphingolipid antigens to iNKT cells. MBL tetramers help measure CD1d positive NKT cells
Respiratory Syncytial Virus (RSV): Continued Research for the Most Prevalent Respiratory Virus Among Children
RSV is a significant respiratory virus in young children, & is the primary cause of hospitalisations, particularly bronchiolitis & pneumonia.