What Exactly is a TCR Tetramer?

What Exactly is a TCR Tetramer?

A TCR Tetramer is a reagent prepared by tetramerising biotinylated antigen-specific TCRs with the help of phycobiliprotein-labelled streptavidin.

MBL International has developed an innovative TCR tetramer reagent. This reagent is created by combining biotinylated antigen-specific TCRs with phycobiliprotein-labelled streptavidin, resulting in a unique and effective product. Furthermore, their TCR Tetramer reagents, specifically designed for cancer antigens (survivin-2B, PBF), have undergone thorough assessment for their staining properties using flow cytometry. The interaction between TCR-peptide and HLA is considered the gold standard for immune responses as it stimulates antigen-specific cytotoxic T lymphocytes (CTL). Through targeting the TCR-peptide/HLA interactions, various immunotherapies have played a crucial role in the treatment of cancer.

Comparison between MHC and TCR Tetramers

StructureMHC/peptideTCR (α chain/β chain)
RecognitionSpecific TCRSpecific MHC/peptide complex
DetectionAntigen-specific T cells Antigen-specific tumours and antigen-presenting cells
・Monitoring of antigen-specific T cells
・Evaluation of the efficacy of cancer immunotherapies
・Quality control of cancer vaccine

MBLI offers TCR Tetramers for the detection and monitoring of antigen-specific T cells.

Product CodeProduct Name 
TS-TCR01-1Human TCR Tetramer-PE (HLA-A*24:02 survivin-2B80-88-AYACNTSTL)
TS-TCR02-1Human TCR Tetramer-PE (HLA-A*24:02 PBF145-153-AYRPVSRNI)

Information provided by MBL.

Caltag Medsystems is the distributor of MBL products in the UK and Ireland. If you have any questions about these products, please contact us.

What Exactly is a TCR Tetramer?
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