Non-classical Major Histocompatibility Complex (MHC) molecules are non-polymorphic proteins that are implicated in both the innate and adaptive immune response. While classical MHCs present antigens to CD8+/CD4+ cells for further immune processing, non-classical MHCs also mediate activation or inhibition in natural killer (NK) cells.
MBL International offers tetramers for the following non-classical MHC targets: HLA-E, Qa-1b, and MR1. Human leukocyte antigen E (HLA-E) is a non-classical class I molecule recognised by natural killer (NK) cells and CD8+ T cells. HLA-E binds to TCR expressed on CD8+ T cells, resulting in T cell activation. The HLA-E tetramer is comprised of human class I HLA-E*01:03 and epitope peptide derived from the HLA-A leader, and it can detect HLA-E*01:03-restricted HLA-A leader3-11-specific NK cells and CD8+ T cells by flow cytometry. The non-classical class I mouse homolog of HLA-E tetramer, Qa-1b tetramer, is now available.
| Product Code | Product Name |
| TB-5106-1 | Tetramer/PE -Qa-1b Qdm (AMAPRTLLL) |
| TB-ME03-1 | HLA-E*01:01 HLA-A leader 3-11 Tetramer-VMAPRTLVL-PE |
| TS-HMRV2-1 | T-Select Human MR1 Tetramer v2-PE |
Information provided by MBL International.
Caltag Medsystems is the distributor of MBL International products in the UK and Ireland. If you have any questions about these products, please contact us.