An article published by Nature earlier this year pointed out that researchers now have to worry about the reproducibility of production antibodies. The fact of the matter is that off-the-shelf antibodies from large distributors can be unreliable tools, often functioning
ProSci’s 5 A’s of Antibody Development Infographic
Antibody development is multi-faceted process that begins with the target to which you wish to develop antibodies against: the antigen. To elicit an immune response we must select the appropriate adjuvant to be mixed with the antigen for immunization. Which
Antibody Basics: Hybridoma
Hybridoma Development Hybridoma technology is the core technique used to develop monoclonal antibodies at ProSci. A hybridoma is a single cell that consists of a cancerous myeloma cell and an immune B-cell which have been fused together into a single
Antibodies & Targets: An Introduction to SAMHD1
SAMHD1, or Sterile Alpha Motif and Histidine/Aspartate domain-containing protein 1, is a dimeric enzyme with phosphohydrolase and nuclease activity that functions as a blockade for virus replication in dendritic cells, monocytes, and macrophages. Its activity is regulated through phosphorylation of
Searching for the Heart of the Problem: Antibodies to Cardiac Myosin Binding Protein
ProSci works with Dr. Sadayappan to create a set of custom antibodies used to study cardiomyopathy. Cardiac Myosin Binding Protein-C (cMyBP-C) is a protein present in cardiac muscle that has been shown to affect the organizational structure of the muscle
Antibody Suppresses AIDS Virus
News from ProSci: Results from a new trial found that an “extremely potent” antibody can dramatically reduce the level of the HIV virus in a patient’s blood. An H9 T cell, blue, is shown infected with HIV, yellow. Researchers at
Kidney Disease Reagents Available
If you’re researching kidney development or disease, then take a look at the range of products we have to help you. Caltag Medsystems has access to a large number of products for use in basic and clinical research including primary renal
Chocolate Brainteaser
Can you solve our chocolate quiz? If you can name all 10 chocolate bars, please email your answer to paula@caltagmedsystems.co.uk for a chance to win a bumper chocolate surprise next month! Definitely not before 20.01 hours… Voodoo in a box
Albumin Removal from Sample Preparations
Biotech Support Group bring you two alternate strategies for albumin removal from sample preparations: AlbuSorb – an albumin binding strategy AlbuVoid – an albumin voiding strategy plus Albutrial, a combined trial kit including 1 gm of AlbuSorb™ and 5 Preps of AlbuVoid™ with
Blood Controls for Flow Cytometry
Routine haematological testing requires the use of reference material during machine set up such that validation prior to analysis of patient samples can be performed. Many also require repeat use of reference controls throughout the running period of the machine,