The exchange of peptides on major histocompatibility complex class II proteins is an area of great interest in the field of immune response. This is because these proteins present exogenous antigens to CD4+ T cells, which play a crucial role in immune monitoring. By conducting functional screening of peptides for MHC Class II binding, we can effectively contribute to vaccine design and the monitoring of disease states and functional vaccination protocols.
Begin with your in-silico findings, use the QuickSwitch™ Class II Quant Tetramer Kit to investigate peptide-MHC binding affinities, and conclude with your very own specialised CD4+ T cell detection reagent!
QuickSwitch™ Class II Tetramer Peptide Exchange and Quantitation Kit utilises a patented technique for exchanging up to ten peptides on an MHC Class II Tetramer. Reduce time and cost with this kit to create your own custom tetramers or to test which peptide sequence has the best peptide-MHC binding affinity. This kit can be used for screening multiple peptides or to create a small amount of your own custom Tetramer in-house. The resulting custom tetramers can be used for multiple applications including screening immunogenic peptides, neoantigen discovery, and many other assays downstream from in-silico selection.
- Create Custom Tetramers with minimal hands-on time
- Quantify Peptide Exchange
- No UV required
| Product Description | ALLELE | Conjugates Available | Quantification Included |
|---|---|---|---|
| QuickSwitch™ Quant HLA-DRB1*01:01 Tetramer Kit | HLA-DRB1*01:01 | PE, APC, BV421 | Yes |
| QuickSwitch™ Quant HLA-DRB1*04:01 Tetramer Kit | HLA-DRB1*04:01 | PE, APC, BV421 | Yes |
| QuickSwitch™ Quant HLA-DRB1*15:01 Tetramer Kit | HLA-DRB1*15:01 | PE, APC, BV421 | Yes |
Information provided by MBL.
Caltag Medsystems is the distributor of MBL products in the UK and Ireland. If you have any questions about these products, please contact us.