The UPS and the autophagic-lysosomal pathway are the two major degradation systems for native & misfolded proteins in eukaryotic cells.
The Ubiquitin-Proteasome System
Special offer on TransFix/EDTA Vacuum Blood Collection Tubes
We are currently offering a 50% discount on our current batch of 3ml TransFix/EDTA Vacuum Blood Collection Tubes that expire in August 2016. Please quote ‘TVTOFFER’ with your order to receive this discount. TransFix stabilises leukocytic antigens in human blood
Small Molecules: Product Highlights
Caltag Medsystems have a vast portfolio of compounds for research – including inhibitors, biochemicals, small molecules, lipids and antibiotics. To view our full range of compounds, please click here. Alternatively, if you know what you are looking for, you can
Microtubules and the Assembly of the Inflammasome Complex
Inflammasomes are assembled from a pattern-recognition receptor, the adapter protein Asc and caspase-1 to process interleukin-1b (IL-1b) and IL-18 in response to microbial components or damage-associated signals. Recently, it was shown that microtubules might have a central role in the
Can you solve our brainteaser?
Chuck caught himself an alligator in the swamp and took it over to Larry’s place to weigh it. It turned out that the tail alone weighed 80 pounds. The head weighed as much as the tail and half the body,
Blood Controls For Flow Cytometry – Samples Available
Cytomark are currently providing free samples of Stabilised Human Whole Blood and CD4 Low & Normal Blood Controls to all UK customers. These blood controls are available immediately for testing and have a 90 day sample stability. To request a sample,
Flagellin – A TLR5/NLRC4 Agonist
Toll-like receptor 5 (TLR5) recognises flagellin from both Gram-positive and Gram-negative bacteria. Activation of the receptor stimulates the production of proinflammatory cytokines, such as TNF-α, through signalling via the adapter proteins MyD88, TIRAP and TRIF. Flagellin is the subunit protein
Pam3CSK4 – a TLR1/2 Agonist
Toll-like receptor 1 (TLR1) recognises pathogen-associated molecular patterns (PAMPS) with a specificity for Gram-positive bacteria. TLR1 recognises peptidoglycan and triacyl lipoproteins in concert with TLR2. Pam3CSK4 is a selective agonist to the TLR1/TLR2 heterodimer complex. It is a cell permeable
CaM Kinase II Assay
CycLex® CaM kinase II Assay Kit measures activity of CaM kinase II in cell lines/tissue homogenates & screens for CaM Kinase inhibitors/activators.