Pam3CSK4 – a TLR1/2 Agonist

Toll-like receptor 1 (TLR1) recognises pathogen-associated molecular patterns (PAMPS) with a specificity for Gram-positive bacteria. TLR1 recognises peptidoglycan and triacyl lipoproteins in concert with TLR2.

Pam₃CSK₄ is a selective agonist to the TLR1/TLR2 heterodimer complex. It is a cell permeable and water soluble synthetic tripalmitoylated lipopeptide that activates the acylated amino terminus of bacterial lipoproteins. Pam₃CSK₄ activates monocytes and macrophages, is a potent and effective immune adjuvant, and is also a potent activator of the pro-inflammatory transcription factor NF-κB.

Product Information

Pam₃Cys-Ser-(Lys)₄. 3HCl (2mg)

Caltag Medsystems is the distributor of Adipogen Life Sciences products in the UK and Ireland. If you have any questions about these products, please contact us.

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References

Buwitt-Beckmann et al (2005). TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides. The Journal of Biological Chemistry 281 (14): 9049 –9057

Buwitt-Beckmann et al (2005). Lipopeptide structure determines TLR2 dependent cell activation level. The FEBS Journal 274 (24): 6354-6364

Muèller et al (2000). Immunostimulation by the synthetic lipopeptide P₃CSK₄: TLR4-independent activation of the ERK1/2 signal transduction pathway in macrophages. Immunology 103: 49-60

Erhard et al (2000). Adjuvant Effects of Various Lipopeptides and Interferon-γ on the Humoral Immune Response of Chickens. Poultry Science 79: 1264–1270

Aliprantis et al (1999). Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285 (5428): 736-9