Non-classical Major Histocompatibility Complex (MHC) molecules are non-polymorphic proteins implicated in both innate and adaptive immune responses.1,2 While classical MHCs present antigens to CD8+/CD4+ cells for further immune processing, non-classical MHCs also mediate activation or inhibition in natural killer (NK) cells.3 MBL
CD1d
CD1d molecules are non-polymorphic MHC class I-like proteins. These are a type of non-classical MHCs. They present phospholipid and glycosphingolipid antigens to invariant Natural Killer T (iNKT) cells, a subset of CD1d-restricted T cells. This axis is involved in the
MHC Class II Tetramers
T cell receptors (TCRs) expressed on the surface of T cells specifically recognise and bind to complexes of major histocompatibility complex (MHC) molecules and peptide fragments. CD4+ T cells, which include helper and regulatory T cells, recognise complexes of MHC class
MHC Class I Tetramers
T cell receptors (TCRs) expressed on the surface of T cells specifically recognise and bind to complexes of major histocompatibility complex (MHC) molecules and peptide fragments expressed on the surface of antigen-presenting cells. CD8+ T cells, also called cytotoxic T
Why is the MHC monomer the ideal choice for your experimental design?

The MHC Monomer is a sub-component of an MHC Tetramer. Biotinylated Monomers are available for most associated Tetramer products.
Flexibility and Expansion with BV421 Tetramers

Adding another marker to a flow cytometry panel can present a challenge when trying to accommodate all markers of interest in one panel. However, there is a solution.
Cervical cancer is the fourth most common cancer affecting women: Antigen-Specific Detection of HPV and HSV

Cervical cancer is the 4th most prevalent cancer among women, and the 7th most common cancer. MBLI provides HPV-related tetramers for use in research.
Defined Immune Response Tracking in Mice: OVA MHC Tetramers

T cell-dependent OVA antigen is used as a model protein for studying antigen-specific immune responses in mice. MBL has OVA related tetramer products.
Protective Role of Invariant Natural Killer T (iNKT) cells

CD1d, non-classical MHC molecules, present phospholipid & glycosphingolipid antigens to iNKT cells. MBL tetramers help measure CD1d positive NKT cells
Ensure Accurate Immune Monitoring Results with Negative Controls

Negative controls aid precision of immune response monitoring. For HLA-A*02:01 alleles, MBLI offers a “Negative Tetramer” in BV421, PE or APC.