T cell receptors (TCRs) expressed on the surface of T cells specifically recognise and bind to complexes of major histocompatibility complex (MHC) molecules and peptide fragments. CD4+ T cells, which include helper and regulatory T cells, recognise complexes of MHC class
MHC Class I Tetramers
T cell receptors (TCRs) expressed on the surface of T cells specifically recognise and bind to complexes of major histocompatibility complex (MHC) molecules and peptide fragments expressed on the surface of antigen-presenting cells. CD8+ T cells, also called cytotoxic T
Why is the MHC monomer the ideal choice for your experimental design?
The MHC Monomer is a sub-component of an MHC Tetramer. Biotinylated Monomers are available for most associated Tetramer products.
Flexibility and Expansion with BV421 Tetramers
Adding another marker to a flow cytometry panel can present a challenge when trying to accommodate all markers of interest in one panel. However, there is a solution.
Cervical cancer is the fourth most common cancer affecting women: Antigen-Specific Detection of HPV and HSV
Cervical cancer is the 4th most prevalent cancer among women, and the 7th most common cancer. MBLI provides HPV-related tetramers for use in research.
Defined Immune Response Tracking in Mice: OVA MHC Tetramers
T cell-dependent OVA antigen is used as a model protein for studying antigen-specific immune responses in mice. MBL has OVA related tetramer products.
Protective Role of Invariant Natural Killer T (iNKT) cells
CD1d, non-classical MHC molecules, present phospholipid & glycosphingolipid antigens to iNKT cells. MBL tetramers help measure CD1d positive NKT cells
Ensure Accurate Immune Monitoring Results with Negative Controls
Negative controls aid precision of immune response monitoring. For HLA-A*02:01 alleles, MBLI offers a “Negative Tetramer” in BV421, PE or APC.
Validation of Neoantigen In Silico Prediction using QuickSwitch™ Kits
Research findings indicate that neoantigens have the potential to activate tumour-specific T-cell-mediated anti-tumour immune responses.
Tetramer Gating Strategy For True Positives Results
Investigators have developed a gating strategy that effectively minimises non-specific staining by incorporating a dump channel.