Protective Role of Irisin in Alzheimer’s Disease

Irisin is a protein cleaved from fibronectin type III domain-containing protein 5 (FNDC5) and has a beneficial role in adipose tissues, bone and brain. A recent study published in Nature Medicine by the labs of O. Arancio, S.Ferreira & F.G. de Felice (Rio de Janeiro, Brazil, New York, US and Kingston, Canada, respectively) showed that FNDC5/Irisin levels are reduced in Alzheimer’s Disease (AD) cerebrospinal fluid in human and mouse and that beneficial effects of exercise on synaptic plasticity and memory in AD models are mediated by FNDC5/Irisin. Addition of AdipoGen Life Sciences’ recombinant Irisin (Prod. No. AG-40B-0136) in a mice model of AD was neuroprotective and rescued Amyloid-β oligomer-induced memory impairment.

AdipoGen Life Sciences provides the best recombinant Irisin/FNDC5 proteins, antibody and ELISA kit to study Irisin and FNDC5 in vitro and in vivo:

– Irisin (rec.) (CHO) (Prod. No. AG-40B-0136)

– Irisin:Fc (human) (rec) (Prod. No. AG-40B-0115) (for in vivo studies)

– Irisin (rec.) (untagged) (E.coli) (Prod. No. AG-40B-0103)

– FNDC5 (rec) (untagged) (Prod. No. AG-40B-0128)

– FNDC5:Fc (human) (rec) (Prod. No. AG-40B-0153)

– anti-Irisin, pAb (IN102) (Prod. No. AG-25B-0027)

– Irisin Competitive ELISA Kit (Prod. No. AG-45A-0046Y)

LIT: Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models: M.V. Lourenko, et al.; Nat. Med. 25, 165 (2019)

Protective Role of Irisin in Alzheimer’s Disease
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