A TCR Tetramer is a reagent prepared by tetramerising biotinylated antigen-specific TCRs with the help of phycobiliprotein-labelled streptavidin.
MBL International has developed an innovative TCR tetramer reagent. This reagent is created by combining biotinylated antigen-specific TCRs with phycobiliprotein-labelled streptavidin, resulting in a unique and effective product. Furthermore, their TCR Tetramer reagents, specifically designed for cancer antigens (survivin-2B, PBF), have undergone thorough assessment for their staining properties using flow cytometry. The interaction between TCR-peptide and HLA is considered the gold standard for immune responses as it stimulates antigen-specific cytotoxic T lymphocytes (CTL). Through targeting the TCR-peptide/HLA interactions, various immunotherapies have played a crucial role in the treatment of cancer.
Comparison between MHC and TCR Tetramers
| MHC TETRAMER | TCR TETRAMER | |
| Structure | MHC/peptide | TCR (α chain/β chain) |
| Recognition | Specific TCR | Specific MHC/peptide complex |
| Detection | Antigen-specific T cells | Antigen-specific tumours and antigen-presenting cells |
| Application | ・Quantification ・Monitoring of antigen-specific T cells | ・Quantification ・Evaluation of the efficacy of cancer immunotherapies ・Quality control of cancer vaccine |
MBLI offers TCR Tetramers for the detection and monitoring of antigen-specific T cells.
| Product Code | Product Name |
| TS-TCR01-1 | Human TCR Tetramer-PE (HLA-A*24:02 survivin-2B80-88-AYACNTSTL) |
| TS-TCR02-1 | Human TCR Tetramer-PE (HLA-A*24:02 PBF145-153-AYRPVSRNI) |
Information provided by MBL.
Caltag Medsystems is the distributor of MBL products in the UK and Ireland. If you have any questions about these products, please contact us.