MBLI offers Assay/Inhibitor screening kits designed to measure the activities of purified kinase for the rapid and sensitive evaluation of inhibitors.
Protein Phosphorylation: Essential Role in the Proper Functioning of Pathways
S100 Proteins Regulate Metabolic and Immune Pathways to Influence Disease State
Involved in diverse cellular pathways & diseases, S100 proteins play a vital role in intricate workings of cells. MBL has a variety of S100 ELISA kits.
Leveraging Anti-Integrin αvβ6 Antibodies for Ulcerative Colitis
MBLI is proud to introduce the Anti-Integrin αvβ6 ELISA Kit that readily allows measurement of anti-integrin αvβ6 antibody levels in human serum.
IL-18 Therapies Targeting Inflammatory Disease
MBL International offers a wide variety of products to help in the research of IL-18.
CD1d Tetramers for Monitoring Invariant Natural Killer T (iNKT) cells
MBL International offers CD1d tetramers prepared by tetramerisation of complexes of CD1d and β2m by PE- or APC- labelled streptavidin.
New B7 Family Immune Checkpoint Proteins
Recently 5 new B7 family ligands, B7-H3, B7-H4, B7-H5, B7-H6 & B7-H7, were identified, all of them possibly of high interest in immunotherapy research.
HVEM – BTLA – LIGHT – CD160 Network
The checkpoint receptors/ligands system HVEM, LIGHT, CD160 and BTLA (CD272) is part of a complex network of overlapping receptor interactions.
OX40 – OX40L Pathway
OX40 is an activating receptor expressed on the surface of activated cytotoxic T cells & Tregs. OX40 activates & amplifies T cell responses.
TIGIT – CD155 – CD112 – CD226 Network
Tumour cells exploit the dominance of the inhibitory TIGIT pathway to avoid immune-mediated destruction.
LAG-3 – Major Histocompatibility Complex (MHC) – T Cell Receptor (TCR) Pathway
Dual inhibition of LAG-3 and other checkpoint pathways may synergistically increase T cell antitumour activity.