AdipoGen Life Sciences has developed a sensitive, specific and fast SARS-CoV-2 Neutralising Antibodies Detection Kit (Prod. No. AG-48B-0002) that can be used to detect the presence of neutralising antibodies against SARS-CoV-2 in serum/plasma in about 2 hours independently of species and isotypes!
This Detection Kit is based on a colourimetric reaction, which measures the binding of the RBD of the Spike S protein from SARS-CoV-2 to its human receptor ACE2. The presence of neutralising/blocking antibodies in the samples are detected by the reduction of the signal indicating the inhibition of the Spike-ACE2 binding.
The SARS-CoV-2 Neutralising Antibodies Detection Kit contains key reagents required to test the presence of functional neutralising antibodies against SARS-CoV-2 present in the serum or plasma. It is an easy, fast and scalable (automation) alternative to the classical neutralisation assays using Vero E6 cells, such as virus neutralisation test (VNT) and pseudo-virus neutralisation test (pVNT) and does not need biosafety requirements.
High Specificity has been confirmed and published
- Comparison of two commercial surrogate ELISAs to detect a neutralizing antibody response to SARS-CoV-2: K. Mueller, et al.; J. Virol. Methods 292, 114122 (2021)
- Evaluation of Two Rapid Lateral Flow Tests and Two Surrogate ELISAs for the Detection of SARS-CoV-2 Specific Neutralizing Antibodies: P. Girl, et al.; SSRN 3963559 (2021)
This kit is administrable in vaccine and therapeutic development as it is suitable for all antibody isotypes and can be used to determine neutralising antibodies in animal models. The kit will also be useful in current COVID-19 investigations of sero-prevalence, assessment of immune response, herd immunity, the longevity of protective immunity, the efficacy of different vaccine candidates as well as tracking infections in animals.
Originally Posted on adipogen.com/covid-19
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