R-spondin 1 (also known as Christine 3) is a member of the R-spondin family that plays a key role in activating canonical WNT/β-catenin signalling. In the absence of R-spondin, the Frizzled receptor (Fz) is internalised through ubiquitination mediated by the ubiquitin ligase RNF43/ZNRF3. This leads to a decrease in Fz on the cell membrane and insufficient activation of Wnt signals.
On the other hand, when R-spondin is present, RNF43/ZNRF3 forms trimers with LGR and R-spondin, leading to its endocytosis. This prevents it from ubiquitinating Fz, resulting in an increase of Fz on the cell membrane and a strong activation of Wnt signals.
Organoid culture typically utilises niche factors that act on Wnt, EGF, BMP and Notch signals that control stem cell differentiation. Among these signals, R-spondin 1 contributes to the activation of Wnt signals.valbumin.
Features
- Expression in E.coli
- Bioactive domain
- Work as Wnt signal activation
| Product Code | Product Name | |
| J2-004 | Recombinant Human R-spondin 1 | 50 µg |
Information provided by MBL.
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