Toll-like receptor 5 (TLR5) recognises flagellin from both Gram-positive and Gram-negative bacteria. Activation of the receptor stimulates the production of proinflammatory cytokines, such as TNF-α, through signalling via the adapter proteins MyD88, TIRAP and TRIF. Flagellin is the subunit protein
Pam3CSK4 – a TLR1/2 Agonist
Toll-like receptor 1 (TLR1) recognises pathogen-associated molecular patterns (PAMPS) with a specificity for Gram-positive bacteria. TLR1 recognises peptidoglycan and triacyl lipoproteins in concert with TLR2. Pam3CSK4 is a selective agonist to the TLR1/TLR2 heterodimer complex. It is a cell permeable
CaM Kinase II Assay
CycLex® CaM kinase II Assay Kit measures activity of CaM kinase II in cell lines/tissue homogenates & screens for CaM Kinase inhibitors/activators.
Caesin Kinase-2 Assay / Inhibitor Screening Kit
The CycLex® CK2 Assay / Inhibitor Screening Kit measures the activity of purified CK2 for rapid & sensitive evaluation of CK2 inhibitors or activators.
IDH Antibodies
MBL offers highly-specific IDH antibodies to mutant forms of IDH1 & IDH2 which can be used to detect mutated IDHs in specimens of low tumour occupancy.