Antibodies – Page 4 – Caltag Medsystems

Antibodies

TIGIT – CD155 – CD112 – CD226 Network

Tumour cells exploit the dominance of the inhibitory TIGIT pathway to avoid immune-mediated destruction.

Dual inhibition of LAG-3 and other checkpoint pathways may synergistically increase T cell antitumour activity.

Targeting CTLA-4 restores immune response by more accumulation, function & survival of T cells, depletion of Tregs & better antitumour response.

Human Ig superfamily receptor proteins of the structural & functional diverse BTN & BTNL families are potentially important immune modulators.

CD40 is a member of the TNF receptor family expressed by APCs and B cells whereas its ligand, CD40L (CD154), is expressed by activated T cells.

Glucocorticoid-induced TNFR-related protein is an activating receptor on the surface of T cells and other immune cells, binding to its ligand GITRL.

CD137 is an activating receptor binding to CD137L, expressed on natural killer (NK) cells & T cells, therefore triggering innate & adaptive immunity.

T cell immunoglobulin & mucin-3 (TIM-3; HAVcr-2) is an immune checkpoint receptor involved in the suppression of both innate & adaptive immune cells.

AdipoGen’s Progranulin (human) ELISA Kit is the only kit that can detect all mutations in the progranulin gene.

MULTICLONALS are recombinant secondary antibodies developed by AdipoGen’s innovative partner Abcalis.