MBLI’s innovative technology, Fluoppi, simplifies the visualisation of protein-protein interaction.
Is your drug candidate able to reverse the T Cell Exhaustion-like state in MBL’s in vitro functional screening assay?
The process of T cell exhaustion & how it can be harnessed for immuno-oncology drug discovery and for immune checkpoint screening of drug candidates.
What’s the KD of my Antibody?
Understanding binding affinity is an important part of the drug discovery process, ensuring that therapeutic antibodies that bind their targets selectively and specifically. It also helps to understand the intermolecular interactions driving biological processes, structural biology, and structure-function relationships. KD
Tetramers
TCRs recognize and bind to complexes composed of MHC molecules and specific peptides expressed on the surface of antigen-presenting cells. While it was once believed that antigen-specific T cells could be detected using soluble MHC/peptide complexes, monomeric MHC/peptide complexes proved
What do mitochondria have to do with mitophagy?
What is mitophagy? It is when damaged mitochondria are removed from the cell by autophagy. The damaged mitochondria end up in lysosomes for their final disposal. This whole process is to maintain and assure proper cellular function. The importance of
Keima-Red for mitophagy detection in living cells
Mitophagy is the selective degradation of old or depolarised mitochondria by autophagy and contributes to maintaining a healthy population of mitochondria. Since damaged mitochondria lead to collapse cell homoeostasis, mitophagy is believed to be protective against diseases related to mitochondrial
FUCCI: Fluorescent Ubiquitination-based Cell Cycle Indicator
FUCCI (Fluorescent Ubiquitination-based Cell Cycle Indicator) is a set of fluorescent probes which enables the visualisation of cell cycle progression in living cells. FUCCI utilises the phase-dependent nature of replication licensing factors Cdt1 and Geminin. A fusion protein of a