T cells – Caltag Medsystems

T cells

State-of-the art pMHC stability assessment

immunAware’s stability assay measures dissociation of pMHC complexes at 37°C. Distinguish between peptides that support formation of stable or unstable pMHC complexes.

easYmers® peptide loadable MHC class I

With immunAware’s peptide receptive easYmers®, you can produce pMHC complexes tailored for your project, in your own lab!

Protective Role of Invariant Natural Killer T (iNKT) cells

CD1d, non-classical MHC molecules, present phospholipid & glycosphingolipid antigens to iNKT cells. MBL tetramers help measure CD1d positive NKT cells

Ensure Accurate Immune Monitoring Results with Negative Controls

Negative controls aid precision of immune response monitoring. For HLA-A*02:01 alleles, MBLI offers a “Negative Tetramer” in BV421, PE or APC.

Immune Checkpoints

ProSci offers reagents that can be used to study the actions of multiple immune checkpoint proteins such as CTLA-4, PD-1, & its ligands PD-L1 & PD-L2.

CD1d Tetramers for Monitoring Invariant Natural Killer T (iNKT) cells

MBL International offers CD1d tetramers prepared by tetramerisation of complexes of CD1d and β2m by PE- or APC- labelled streptavidin.

HVEM – BTLA – LIGHT – CD160 Network

The checkpoint receptors/ligands system HVEM, LIGHT, CD160 and BTLA (CD272) is part of a complex network of overlapping receptor interactions.

OX40 – OX40L Pathway

OX40 is an activating receptor expressed on the surface of activated cytotoxic T cells & Tregs. OX40 activates & amplifies T cell responses.

LAG-3 – Major Histocompatibility Complex (MHC) – T Cell Receptor (TCR) Pathway

Dual inhibition of LAG-3 and other checkpoint pathways may synergistically increase T cell antitumour activity.

CTLA-4 [CD152] – CD80 – CD86 – CD28 Network

Targeting CTLA-4 restores immune response by more accumulation, function & survival of T cells, depletion of Tregs & better antitumour response.

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