Protective role for IL-36 cytokines in obesity and metabolic disease

Interleukin-36α, β and γ (IL-36α, β and γ), members of the interleukin-1 (IL-1) family, are pro-inflammatory cytokines mainly involved in skin inflammatory diseases, but also in the inflammation of lung or gut. Recently, the lab of Prof. Patrick T. Walsh (Trinity College Dublin, Ireland) describes in Nature Communication a new protective role of the IL-36 family of cytokines in obesity and metabolic diseases. They observed that IL-36γ is increased in serum of obese patients with diabetes, indicating that elevated IL-36 cytokines may play a protective role in reducing blood sugar levels. IL-36 cytokines function by changing the composition of the intestinal microbiome towards a more metabolically healthy state. IL-36 cytokines enhance mucus-secretion from goblet cells in the colon, which promote the outgrowth of the commensal bacterial strain Akkermansia muciniphila, known to play an important protective role against obesity and metabolic dysfunction.

AdipoGen Life Sciences provides a Sensitive and Specific ELISA Kit to measure IL-36γ in serum/plasma:

– IL-36γ (human) ELISA Kit (Prod. No. AG-45B-0008)

AdipoGen Life Sciences is a Leader in the IL-36 Research field, providing a broad range of high quality ELISA Kits, Proteins and Antibodies:

– IL-36α/IL-36γ (human) Tandem ELISA Kit (Prod. No. AG-45B-4502)

– IL-36α (human) ELISA Kit (Prod. No. AG-45B-0013)

– IL-36β (human) Matched Pair Detection Set (Prod. No. AG-46B-0009)

– IL-36Ra (aa 3-156) (mouse) (rec.) (untagged) (Prod. No. AG-40B-0096)

– IL-36α (aa 8-160) (mouse) (rec.) (untagged) (Prod. No. AG-40B-0098)

– IL-36β (aa 31-183) (mouse) (rec.) (untagged) (Prod. No. AG-40B-0099)

– IL-36γ (aa 13-164) (mouse) (rec.) (untagged) (Prod. No. AG-40B-0100)

 

LIT: Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction: F. Giannoudaki, et al.; Nat. Commun. 10, 4003 (2019)

Protective role for IL-36 cytokines in obesity and metabolic disease
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