ProSci offers reagents that can be used to study the actions of multiple immune checkpoint proteins such as CTLA-4, PD-1, & its ligands PD-L1 & PD-L2.
Immune Checkpoints
Viral Infectious Diseases
To support research & studies into infectious diseases, ProSci has reagents for the study of many viral disease agents inc. Covid, HIV, & Influenza.
The Role of Monoclonal Antibodies & Biosimilars in Life Science Research
mAbs (biosimilars) as tools to research novel new therapies and uncover effective off-target application.
Insights into the Molecular Mechanisms Regulating Necroptosis
This white paper details findings in molecular mechanisms that govern necroptosis related to RIPK & details #2283 use to analyse expression of RIPK3.
Exploring the Roles of RIPKs in Immune Responses, Inflammation, and Cell Death: Recent Findings
ProSci has 25+ years expertise in developing antibodies. This white paper details use of RIPK antibodies & findings on RIPKs in signalling pathways.
A Deep Dive into the Hidden Power of Programmed Cell Death: Unlocking Therapeutic Potential with Antibodies
ProSci has 25+ years of expertise in developing antibodies. This white paper details use of ProSci antibodies in the study of programmed cell death.
PD-1: Expanding Beyond Cancer Research
ProSci details the importance of PD-1 antibodies are important in resolving complex interactions between the immune system & pathological conditions.
HVEM – BTLA – LIGHT – CD160 Network
The checkpoint receptors/ligands system HVEM, LIGHT, CD160 and BTLA (CD272) is part of a complex network of overlapping receptor interactions.
OX40 – OX40L Pathway
OX40 is an activating receptor expressed on the surface of activated cytotoxic T cells & Tregs. OX40 activates & amplifies T cell responses.
TIGIT – CD155 – CD112 – CD226 Network
Tumour cells exploit the dominance of the inhibitory TIGIT pathway to avoid immune-mediated destruction.