cancer – Page 3 – Caltag Medsystems

cancer

CTLA-4 [CD152] – CD80 – CD86 – CD28 Network

Targeting CTLA-4 restores immune response by more accumulation, function & survival of T cells, depletion of Tregs & better antitumour response.

Butyrophilin-like Proteins & Other Immune Checkpoint Proteins

Human Ig superfamily receptor proteins of the structural & functional diverse BTN & BTNL families are potentially important immune modulators.

CD40 – CD40L Pathway

CD40 is a member of the TNF receptor family expressed by APCs and B cells whereas its ligand, CD40L (CD154), is expressed by activated T cells.

GITR – GITRL Pathway

Glucocorticoid-induced TNFR-related protein is an activating receptor on the surface of T cells and other immune cells, binding to its ligand GITRL.

CD137 – CD137L Pathway

CD137 is an activating receptor binding to CD137L, expressed on natural killer (NK) cells & T cells, therefore triggering innate & adaptive immunity.

TIM-3 – Galectin-9 Pathway

T cell immunoglobulin & mucin-3 (TIM-3; HAVcr-2) is an immune checkpoint receptor involved in the suppression of both innate & adaptive immune cells.

ICOS [CD278] – ICOSL [CD275] Pathway

ICOS/ICOSL signalling leads to the activation, proliferation and survival of cytotoxic T cells, as well as the survival of memory T cells.

PD-1 [CD279]/PD-L1 [CD274] Pathway

The PD-1/PD-L1 or PD-L2 signalling pathway is a negative regulatory mechanism that inhibits T cell proliferation and cytokine production.

SURAMIN – A Multifunctional Small Molecule with over 100 Years of History

Suramin is a multifunctional molecule with a wide array of potential applications, from parasitic and viral diseases to cancer, snakebite and autism.

Nano Vaccines Induce T Cell Immunity and Control of Tumour Growth

Using nanoparticle technology in making vaccines for infectious diseases/cancer is advancing & enhances the immunogenicity of some vaccine candidates.