The Inflammasome regulates Hematopoiesis through Cleavage of the Factor GATA1

Inflammasomes are large multimolecular complexes involved in innate immune and inflammatory responses. A recent study published by the lab of Prof. Victoriano Mulero (Universidad de Murcia, Spain) describes a new function of the inflammasome as a regulator of the balance between erythroid and myeloid differentiation during hematopoiesis. Activation of the inflammasome and caspase-1 results in the cleavage of the master erythroid transcription factor GATA1, with a decrease in erythrocyte differentiation and in the increase of myeloid cell differentiation.

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– anti-Caspase-1 (p20) (mouse), mAb (Casper-1) (Prod. No. AG-20B-0042)

– anti-Caspase-1 (p20) (human), mAb (Bally-1) (Prod. No. AG-20B-0048)

– anti-NLRP3/NALP3, mAb (Cryo-2) (Prod. No. AG-20B-0014)

– anti-Asc, pAb (AL177) (Prod. No. AG-25B-0006)

– anti-Caspase-4 /11 (p20), mAb (Flamy-1) (Prod. No. AG-20B-0060)

– anti-NLRP6/NALP6 (human), mAb (Clint-1) (Prod. No. AG-20B-0046)

– MCC950 . sodium salt [NLRP3 Inhibitor] (Prod. No. AG-CR1-3615)

– Monosodium urate (ready-to-use) [NLRP3 Activator] (Prod. No. AG-CR1-3951)

LIT: Inflammasome regulates hematopoiesis through cleavage of the master erythroid transcription factor GATA1: S.D. Tyrkalska, et al.; Immunity 51, 50 (2019)

The Inflammasome regulates Hematopoiesis through Cleavage of the Factor GATA1
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