COVID-19 infected cells can be recognized by T-cells only after SARS-CoV-2 peptides are processed and presented in the context of self MHCs. Identifying these peptides have essential utilities: Immune monitoring: Using peptide-MHC tetramers to assess vaccine-induced immunity Designing potent vaccines
Coronavirus (COVID-19) Research Tools
Recently, scientists have discovered a novel strain of Coronavirus (COVID-19) that is more deadly than SARS-CoV and MERS-CoV combined. This has caused a massive viral outbreak globally, and due to the lack of information about this strain, there are limited
Clinically relevant Mesenchymal Stem Cells
Rapid advancements in mesenchymal stem cells (MSCs) research are shedding light on disease processes of musculoskeletal tissue, tissue regeneration, immune modulation and epigenetics. To further the understanding of MSCs disease mechanisms and therapeutic approaches, we offer Renovos research-grade mesenchymal stem
Healthy & Diseased Mesenchymal Stem Cells and Plates
Caltag Medsystems is now offering MSCs from donors of clinically relevant age range. Mesenchymal stem cells (MSCs) from osteoarthritic donors have been used extensively as research tools and can be used for Regenerative Medicine, Musculoskeletal Diseases, Immuno Modulation and Epigenetics. To aid the research of
Fresh and Frozen LeukoPaks
Apheresis was first described over 100 years ago and has been used as a therapy for a number of different diseases, including sickle cell anemia and certain types of cancer. The use of apheresis as a method for isolating enriched
Protective role for IL-36 cytokines in obesity and metabolic disease
Interleukin-36α, β and γ (IL-36α, β and γ), members of the interleukin-1 (IL-1) family, are pro-inflammatory cytokines mainly involved in skin inflammatory diseases, but also in the inflammation of lung or gut. Recently, the lab of Prof. Patrick T. Walsh
Stress granules inhibit NLRP3 inflammasome activation by sequestering the helicase DDX3X
Inflammasomes are large multimolecular complexes involved in innate immune response and driving cell fate towards cell death, called pyroptosis. Stress granules are aggregates formed during cellular stress with pro-survival role composed of proteins and mRNA molecules. Recently, the lab of
The Inflammasome regulates Hematopoiesis through Cleavage of the Factor GATA1
Inflammasomes are large multimolecular complexes involved in innate immune and inflammatory responses. A recent study published by the lab of Prof. Victoriano Mulero (Universidad de Murcia, Spain) describes a new function of the inflammasome as a regulator of the balance
OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin
Asprosin is a fasting-induced hormone that increases plasma glucose levels in the liver. It also stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an unknown G protein-coupled receptor (GPCR). In a recent study, the lab of
Extracellular Vesicles Containing eNAMPT Extend Lifespan
A recent study published in Cell Metabolism by the lab of Shin-Ichiro Ima (Washington University School of Medicine) shows that the circulating levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT), a key NAD+ biosynthetic enzyme in mammals, decline with age in mice