General Information

Fibrinogen-like Protein 1 (FGL1) – A Major Ligand of LAG-3

LAG-3 is a coinhibitory immune checkpoint receptor that inhibits T cell response by binding to MHC-II. In a recent study published in Cell, the lab of Prof Lieping Chen (Yale University, US) identifies Fibrinogen-like protein 1 (FGL1), a molecule secreted

Protective Role of Irisin in Alzheimer’s Disease

Irisin is a protein cleaved from fibronectin type III domain-containing protein 5 (FNDC5) and has a beneficial role in adipose tissues, bone and brain. A recent study published in Nature Medicine by the labs of O. Arancio, S.Ferreira & F.G.

Manganese (Mn2+) as a New Activator of the NLRP3 Inflammasome in the Brain

Inflammasomes are implicated in physiological and pathological inflammation including neurodegenerative disorders such Parkinson or Alzheimer diseases. Divalent manganese (Mn2+) activates chronic inflammation leading to increase of neurotoxicity. Recently, the lab of A.G. Kanthasamy (Iowa State University, US) showed that Mn2+ activates

Erythroferrone (human) ELISA Kit – The only Specific & Sensitive Assay on the Market!

Sandwich ELISA Kit based on two antibodies for the in vitro quantitative determination of human Erythroferrone in supernatants, serum and plasma.

Apoptosis Detection Kits

In general, early apoptosis can be determined by Mitochondrial membrane ΔΨm assay, Annexin V-FITC/PI assay and Caspase-3 assay. Late apoptosis can be determined by TUNEL, DNA ladder assay and DNA content analysis. Elabscience® provides simple and sensitive solutions for detection

MHC Class I & II Tetramers, MHC Monomers and CD1d Tetramers

TCRs recognize and bind to complexes composed of MHC molecules and specific peptides expressed on the surface of antigen-presenting cells. We have tetramerized and biotinylated with streptavidin to maintain stable binding to multiple TCR, enabling MHC/peptide tetramers to be used

Monomers

Biotinylated MHC monomers, the building blocks of MHC tetramers, are now available for tetramer construction flexibility and novel applications. See All Monomer Products

CHP Histopathology

After being degraded by specific enzymes, the triple helical collagen molecule becomes thermally unstable and spontaneously unfolds at body temperature, leaving denatured collagen fragments covalently crosslinked within the partially degraded matrix.[1,2] Such denatured collagen is a hallmark indicator of inflammation and tissue

3D Cell Cultures

Key Features of ScienCell’s 3D Cell Culture Products Convenient: Ready-To-Use 3D spheroids are delivered frozen. Comprehensive: All-Inclusive 3D Culture Kits contain everything you need for performing 3D cell culture. Easy-to-use: No prior experience in 3D cell culture is required. Functional: Cell-specific functional markers are

Recombinant Monoclonal Antibodies [RecMAbs™] – Produced with No Use of Animals

Antibody phage display is an in vitro technology to generate recombinant monoclonal antibodies (RecMAbs™) without the use of animals.